Cancer slice

Colorectal Adenocarcinoma (TCGA, PanCancer Atlas)

450 records, 90 actionable signals, and 415 hotspot records in this source-aligned cancer slice.

Variant	Cancer	Evidence	Frequency	Sources
KRAS p.G12D substitution	COADREAD	DriverHotspotActionable	10.9%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.G12V substitution	COADREAD	DriverHotspotActionable	9.2%	cBioPortal, TCGA Pan-Cancer Atlas
BRAF p.V600E substitution	COADREAD	DriverHotspotActionable	9.0%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.G13D substitution	COADREAD	DriverHotspotActionable	6.9%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.E545K substitution	COADREAD	DriverHotspotActionable	6.6%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.H1047R substitution	COADREAD	DriverHotspotActionable	3.4%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.A146T substitution	COADREAD	DriverHotspotActionable	3.0%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.G12C substitution	COADREAD	DriverHotspotActionable	2.8%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.R88Q substitution	COADREAD	DriverHotspotActionable	2.8%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.E542K substitution	COADREAD	DriverHotspotActionable	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.G12A substitution	COADREAD	DriverHotspotActionable	1.9%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.G12S substitution	COADREAD	DriverHotspotActionable	1.5%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.C420R substitution	COADREAD	DriverHotspotActionable	0.75%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.H1047Y substitution	COADREAD	DriverHotspotActionable	0.75%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.E726K substitution	COADREAD	DriverHotspotActionable	0.75%	cBioPortal, TCGA Pan-Cancer Atlas
ERBB2 p.V842I substitution	COADREAD	DriverHotspotActionable	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
ALK p.R401* substitution	COADREAD	DriverHotspotActionable	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.Q61H substitution	COADREAD	DriverHotspotActionable	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.Q61K substitution	COADREAD	DriverHotspotActionable	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.E545A substitution	COADREAD	DriverHotspotActionable	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.R108H substitution	COADREAD	DriverHotspotActionable	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.V344G substitution	COADREAD	DriverHotspotActionable	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.E970K substitution	COADREAD	DriverHotspotActionable	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.R357Q substitution	COADREAD	DriverHotspotActionable	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.Y1021C substitution	COADREAD	DriverHotspotActionable	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.Q546K substitution	COADREAD	DriverHotspotActionable	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
ERBB2 p.V777L substitution	COADREAD	DriverHotspotActionable	0.37%	cBioPortal, TCGA Pan-Cancer Atlas
BRAF p.D594N substitution	COADREAD	DriverHotspotActionable	0.37%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.Q61R substitution	COADREAD	DriverHotspotActionable	0.37%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.G13C substitution	COADREAD	DriverHotspotActionable	0.37%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.K117N substitution	COADREAD	DriverHotspotActionable	0.37%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.K117N substitution	COADREAD	DriverHotspotActionable	0.37%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.G12R substitution	COADREAD	DriverHotspotActionable	0.37%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.T1025A substitution	COADREAD	DriverHotspotActionable	0.37%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.D350G substitution	COADREAD	DriverHotspotActionable	0.37%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.E110del deletion	COADREAD	DriverHotspotActionable	0.37%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.N345K substitution	COADREAD	DriverHotspotActionable	0.37%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.M1043I substitution	COADREAD	DriverHotspotActionable	0.37%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.E81K substitution	COADREAD	DriverHotspotActionable	0.37%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.M1043I substitution	COADREAD	DriverHotspotActionable	0.37%	cBioPortal, TCGA Pan-Cancer Atlas