Variants
Highlighted variant dossiers
The static build generates 900 prioritized variant pages from hotspot, driver, actionability, recurrence, and source-support signals. The full searchable catalog remains available in Explore.
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| BRAF p.V600E | THPA | DriverHotspotActionable | 58.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| IDH1 p.R132H | DIFG | DriverHotspotActionable | 69.6% | TCGA Pan-Cancer Atlas, cBioPortal |
| BRAF p.V600E | SKCM | DriverHotspotActionable | 35.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12D | PAAD | DriverHotspotActionable | 27.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12C | LUAD | DriverHotspotActionable | 12.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.H1047R | BRCA | DriverHotspotActionable | 12.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12V | PAAD | DriverHotspotActionable | 18.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12D | COADREAD | DriverHotspotActionable | 10.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | CESC | DriverHotspotActionable | 12.7% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12V | COADREAD | DriverHotspotActionable | 9.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| BRAF p.V600E | COADREAD | DriverHotspotActionable | 9.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12V | LUAD | DriverHotspotActionable | 7.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | BRCA | DriverHotspotActionable | 6.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E542K | BRCA | DriverHotspotActionable | 4.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G13D | COADREAD | DriverHotspotActionable | 6.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.R88Q | UCEC | DriverHotspotActionable | 7.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| BRAF p.V600K | SKCM | DriverHotspotActionable | 8.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | COADREAD | DriverHotspotActionable | 6.6% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.S249C | BLCA | DriverHotspotActionable | 7.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12R | PAAD | DriverHotspotActionable | 14.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12D | UCEC | DriverHotspotActionable | 6.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | BLCA | DriverHotspotActionable | 7.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.H1047R | UCEC | DriverHotspotActionable | 5.6% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | HNSC | DriverHotspotActionable | 5.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E542K | CESC | DriverHotspotActionable | 7.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| BRAF p.V600R | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.V600E | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.V600V | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.V600G | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.V600K | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.V600M | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.G469A | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.G469R | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.G469S | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.G469E | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.G469V | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.G469G | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.G469* | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.D594E | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.D594V | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.D594G | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.D594H | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.D594Y | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.D594N | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| EGFR p.L858R | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| EGFR p.T790T | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| EGFR p.T790M | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| EGFR p.A289T | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| EGFR p.A289D | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| EGFR p.A289V | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| EGFR p.A289I | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| EGFR p.A289N | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| EGFR p.E746_A750del | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| EGFR p.K754_I759del | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| EGFR p.E746_T751delinsA | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| EGFR p.L747_P753delinsS | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| EGFR p.L747_S752del | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| EGFR p.K745_E746insVPVAIK | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| EGFR p.T751_A755del | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| EGFR p.L747_T751del | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| EGFR p.L747_E749del | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| EGFR p.T751_E758del | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| EGFR p.S752_I759del | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| ERBB2 p.S310S | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| ERBB2 p.S310F | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| ERBB2 p.S310Y | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| ERBB2 p.L755P | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| ERBB2 p.L755A | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| ERBB2 p.L755S | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| ERBB2 p.L755W | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| ERBB2 p.L755L | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| ERBB2 p.L755M | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| FGFR3 p.S249C | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132C | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132S | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132G | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132H | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132I | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH1 p.R132L | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| IDH2 p.R172R | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |