Variant dossier
EGFR p.T790T
Static provenance dossier for a highlighted variant. Use the linked Explore state to compare related records across the full catalog.
DriverHotspotActionable
EGFR p.T790T
No mechanism summary is present in the seed catalog for this record.
Not reported
60
1
- Coordinate
- No coordinate
- Cancer types
- Not reported
- Pathway
- RTK-RAS
- Therapy context
- Osimertinib, Erlotinib, Gefitinib, Afatinib, Dacomitinib
- Clinical annotation
- N/A
- Citations
- CancerHotspots:EGFR:T790
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| BRAF p.V600E | THPA | DriverHotspotActionable | 58.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| BRAF p.V600E | SKCM | DriverHotspotActionable | 35.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12D | PAAD | DriverHotspotActionable | 27.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12C | LUAD | DriverHotspotActionable | 12.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12V | PAAD | DriverHotspotActionable | 18.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12D | COADREAD | DriverHotspotActionable | 10.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12V | COADREAD | DriverHotspotActionable | 9.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| BRAF p.V600E | COADREAD | DriverHotspotActionable | 9.0% | cBioPortal, TCGA Pan-Cancer Atlas |