Cancer slice

Esophageal Adenocarcinoma (TCGA, PanCancer Atlas)

158 records, 15 actionable signals, and 148 hotspot records in this source-aligned cancer slice.

Variant	Cancer	Evidence	Frequency	Sources
PIK3CA p.E545K substitution	ESCA	DriverHotspotActionable	3.3%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.H1047L substitution	ESCA	DriverHotspotActionable	1.6%	cBioPortal, TCGA Pan-Cancer Atlas
ERBB2 p.V777L substitution	ESCA	DriverHotspotActionable	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
ERBB2 p.S310F substitution	ESCA	DriverHotspotActionable	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.G12D substitution	ESCA	DriverHotspotActionable	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.E726K substitution	ESCA	DriverHotspotActionable	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
ERBB2 p.M774dup insertion	ESCA	DriverHotspotActionable	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
ERBB2 p.V777M substitution	ESCA	DriverHotspotActionable	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.G598E substitution	ESCA	DriverHotspotActionable	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.K111N substitution	ESCA	DriverHotspotActionable	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.G118D substitution	ESCA	DriverHotspotActionable	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.E970K substitution	ESCA	DriverHotspotActionable	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.H1047R substitution	ESCA	DriverHotspotActionable	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.Q546H substitution	ESCA	DriverHotspotActionable	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.M1043I substitution	ESCA	DriverHotspotActionable	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.R175H substitution	ESCA	DriverHotspot	5.5%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.R248Q substitution	ESCA	DriverHotspot	4.9%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.R248W substitution	ESCA	DriverHotspot	3.3%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.R273H substitution	ESCA	DriverHotspot	3.3%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.R282W substitution	ESCA	DriverHotspot	2.7%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.R213* substitution	ESCA	DriverHotspot	2.2%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.Y220C substitution	ESCA	DriverHotspot	2.2%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.R273C substitution	ESCA	DriverHotspot	2.2%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.R196* substitution	ESCA	DriverHotspot	1.6%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.R306* substitution	ESCA	DriverHotspot	1.6%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.R342* substitution	ESCA	DriverHotspot	1.6%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.C135F substitution	ESCA	DriverHotspot	1.6%	cBioPortal, TCGA Pan-Cancer Atlas
CDKN2A p.H83Y substitution	ESCA	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
FBXW7 p.R505G substitution	ESCA	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
NFE2L2 p.E79Q substitution	ESCA	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.C176F substitution	ESCA	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.C275F substitution	ESCA	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.E198* substitution	ESCA	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
SMARCA4 p.T910M substitution	ESCA	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.G245S substitution	ESCA	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.I255del deletion	ESCA	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.W91* substitution	ESCA	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
PTPRT p.L668V substitution	ESCA	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.R175G substitution	ESCA	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.E294* substitution	ESCA	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas