Cancer slice
Lung Squamous Cell Carcinoma (TCGA, PanCancer Atlas)
296 records, 30 actionable signals, and 293 hotspot records in this source-aligned cancer slice.
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| PIK3CA p.E545K | LUSC | DriverHotspotActionable | 2.7% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E542K | LUSC | DriverHotspotActionable | 2.7% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.H1047R | LUSC | DriverHotspotActionable | 1.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.S249C | LUSC | DriverHotspotActionable | 0.83% | cBioPortal, TCGA Pan-Cancer Atlas |
| EGFR p.L861Q | LUSC | DriverHotspotActionable | 0.41% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545Q | LUSC | DriverHotspotActionable | 0.41% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.H1047L | LUSC | DriverHotspotActionable | 0.41% | cBioPortal, TCGA Pan-Cancer Atlas |
| BRAF p.G469R | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| BRAF p.D594N | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| EGFR p.E746_A750del | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| BRAF p.G469A | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12V | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12A | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.Q61H | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.G380R | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR2 p.C382R | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| KIT p.N822K | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G13C | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.C420R | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.G118D | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E726K | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.R38L | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.G106V | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.D350G | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.R108L | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E453K | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E542V | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.M1004V | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E81K | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.K111N | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R158L | LUSC | DriverHotspot | 2.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.V157F | LUSC | DriverHotspot | 2.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R273L | LUSC | DriverHotspot | 1.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| NFE2L2 p.E79Q | LUSC | DriverHotspot | 1.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.Y234C | LUSC | DriverHotspot | 1.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.G245C | LUSC | DriverHotspot | 1.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| NFE2L2 p.R34G | LUSC | DriverHotspot | 1.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.E298* | LUSC | DriverHotspot | 1.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.Y163C | LUSC | DriverHotspot | 1.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| NFE2L2 p.G31A | LUSC | DriverHotspot | 1.0% | cBioPortal, TCGA Pan-Cancer Atlas |