Cancer slice

Sarcoma (TCGA, PanCancer Atlas)

89 records, 8 actionable signals, and 88 hotspot records in this source-aligned cancer slice.

Variant	Cancer	Evidence	Frequency	Sources
RET p.M918T substitution	SOFT_TISSUE	DriverHotspotActionable	2.2%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.H1047R substitution	SOFT_TISSUE	DriverHotspotActionable	0.78%	cBioPortal, TCGA Pan-Cancer Atlas
BRAF p.G469A substitution	SOFT_TISSUE	DriverHotspotActionable	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
KRAS p.G13C substitution	SOFT_TISSUE	DriverHotspotActionable	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
IDH1 p.R132C substitution	SOFT_TISSUE	DriverHotspotActionable	0.39%	TCGA Pan-Cancer Atlas, cBioPortal
KRAS p.Q61H substitution	SOFT_TISSUE	DriverHotspotActionable	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.Q546K substitution	SOFT_TISSUE	DriverHotspotActionable	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
PIK3CA p.N345K substitution	SOFT_TISSUE	DriverHotspotActionable	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
HRAS p.Q61R substitution	SOFT_TISSUE	DriverHotspot	7.3%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.R175H substitution	SOFT_TISSUE	DriverHotspot	1.6%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.R248W substitution	SOFT_TISSUE	DriverHotspot	1.2%	cBioPortal, TCGA Pan-Cancer Atlas
EPAS1 p.P531L substitution	SOFT_TISSUE	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
EPAS1 p.Y532C substitution	SOFT_TISSUE	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
HRAS p.G13R substitution	SOFT_TISSUE	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
HRAS p.Q61K substitution	SOFT_TISSUE	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.C275Y substitution	SOFT_TISSUE	DriverHotspot	0.78%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.G244S substitution	SOFT_TISSUE	DriverHotspot	0.78%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.R213* substitution	SOFT_TISSUE	DriverHotspot	0.78%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.M237I substitution	SOFT_TISSUE	DriverHotspot	0.78%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.K132R substitution	SOFT_TISSUE	DriverHotspot	0.78%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.C238Y substitution	SOFT_TISSUE	DriverHotspot	0.78%	cBioPortal, TCGA Pan-Cancer Atlas
EPAS1 p.P531S substitution	SOFT_TISSUE	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
EPAS1 p.P531A substitution	SOFT_TISSUE	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
MTOR p.I2500F substitution	SOFT_TISSUE	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
GTF2I p.L424H substitution	SOFT_TISSUE	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
HRAS p.Q61L substitution	SOFT_TISSUE	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.E285V substitution	SOFT_TISSUE	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.R161Q substitution	SOFT_TISSUE	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
ATM p.R337C substitution	SOFT_TISSUE	DriverHotspot	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
DICER1 p.D1709N substitution	SOFT_TISSUE	DriverHotspot	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
MYC p.P74L substitution	SOFT_TISSUE	DriverHotspot	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
MYC p.P74S substitution	SOFT_TISSUE	DriverHotspot	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
NRAS p.Q61L substitution	SOFT_TISSUE	DriverHotspot	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
MED12 p.G44D substitution	SOFT_TISSUE	DriverHotspot	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR1 p.N577K substitution	SOFT_TISSUE	DriverHotspot	0.39%	TCGA Pan-Cancer Atlas, cBioPortal
TP53 p.W91* substitution	SOFT_TISSUE	DriverHotspot	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.L194R substitution	SOFT_TISSUE	DriverHotspot	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
PTEN p.D92V substitution	SOFT_TISSUE	DriverHotspot	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.Q192del deletion	SOFT_TISSUE	DriverHotspot	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
TP53 p.G262del deletion	SOFT_TISSUE	DriverHotspot	0.39%	cBioPortal, TCGA Pan-Cancer Atlas