Gene dossier

BRCA1

8,629 mutation records across 2 cancer labels and 3 source families.

8629 actionable0 hotspotsDNA Repair

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
BRCA1 p.S1434N substitution	DLBCLNOS	Likely DriverActionable	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
BRCA1 p.E673K substitution	DLBCLNOS	Likely DriverActionable	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
BRCA1 p.Cys64Gly substitution	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Cys64Gly substitution	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Cys61Gly substitution	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Cys61Gly substitution	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Glu23fs Microsatellite	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Glu23fs Microsatellite	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Leu392fs deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Leu392fs deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Glu765_Ser766insTer Microsatellite	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Glu765_Ser766insTer Microsatellite	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Lys894fs deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Lys894fs deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Asn1002fs deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Asn1002fs deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Arg1203Ter substitution	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Arg1203Ter substitution	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Glu1250Ter substitution	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Glu1250Ter substitution	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Ser1253fs Microsatellite	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Ser1253fs Microsatellite	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Asn1355fs deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Asn1355fs deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Arg1443Ter substitution	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Arg1443Ter substitution	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Arg1443Gly substitution	UNSPEC	VUSActionable	Not reported	ClinVar
BRCA1 p.Arg1443Gly substitution	UNSPEC	VUSActionable	Not reported	ClinVar
BRCA1 p.Gln1756fs duplication	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA1 p.Gln1756fs duplication	UNSPEC	DriverActionable	Not reported	ClinVar