Gene dossier

BRCA2

11,267 mutation records across 4 cancer labels and 4 source families.

11267 actionable2 hotspotsDNA Repair

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
BRCA2 p.E1514Q substitution	CHOL	Likely DriverActionable	2.8%	cBioPortal, TCGA Pan-Cancer Atlas
BRCA2 p.N1805D substitution	UCS	Likely DriverActionable	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
BRCA2 p.L3180F substitution	UCS	Likely DriverActionable	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
BRCA2 p.M1090L substitution	UCS	Likely DriverActionable	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
BRCA2 p.Q3398R substitution	UCS	Likely DriverActionable	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
BRCA2 p.T2367Lfs*9 frameshift	UCS	Likely DriverActionable	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
BRCA2 p.F2841Kfs*24 frameshift	UM	Likely DriverActionable	1.3%	cBioPortal, TCGA Pan-Cancer Atlas
BRCA2 p.S2303S substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
BRCA2 p.S2303F substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
BRCA2 c.7004_7007+2del deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA2 c.7004_7007+2del deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA2 p.Leu2092fs deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA2 p.Leu2092fs deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA2 p.Glu2198fs deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA2 p.Glu2198fs deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA2 p.Leu1908fs Microsatellite	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA2 p.Leu1908fs Microsatellite	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA2 p.Ala938Profs deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA2 p.Ala938Profs deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA2 p.Thr1302del Microsatellite	UNSPEC	VUSActionable	Not reported	ClinVar
BRCA2 p.Thr1302del Microsatellite	UNSPEC	VUSActionable	Not reported	ClinVar
BRCA2 p.Ser1982fs deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA2 p.Ser1982fs deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA2 p.Asn257fs deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA2 p.Asn257fs deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA2 p.Glu2846fs Microsatellite	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA2 p.Glu2846fs Microsatellite	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA2 p.Ala2911Glu substitution	UNSPEC	VUSActionable	Not reported	ClinVar
BRCA2 p.Ala2911Glu substitution	UNSPEC	VUSActionable	Not reported	ClinVar
BRCA2 p.Thr2722Arg substitution	UNSPEC	DriverActionable	Not reported	ClinVar