Gene dossier
CDH1
1,361 mutation records across 5 cancer labels and 4 source families.
0 actionable26 hotspotsNot reported
Top records
Prioritized variant evidence
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| CDH1 p.D854Kfs*8 | ACC | Likely Driver | 1.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| CDH1 p.Q23* | BRCA | DriverHotspot | 0.75% | cBioPortal, TCGA Pan-Cancer Atlas |
| CDH1 p.D254Y | STAD | DriverHotspot | 0.69% | cBioPortal, TCGA Pan-Cancer Atlas |
| CDH1 p.Y190C | STAD | DriverHotspot | 0.46% | cBioPortal, TCGA Pan-Cancer Atlas |
| CDH1 p.R63* | BRCA | DriverHotspot | 0.38% | cBioPortal, TCGA Pan-Cancer Atlas |
| CDH1 p.R63P | BLCA | DriverHotspot | 0.24% | cBioPortal, TCGA Pan-Cancer Atlas |
| CDH1 p.R63* | BLCA | DriverHotspot | 0.24% | cBioPortal, TCGA Pan-Cancer Atlas |
| CDH1 p.D288V | STAD | DriverHotspot | 0.23% | cBioPortal, TCGA Pan-Cancer Atlas |
| CDH1 p.D288N | BRCA | DriverHotspot | 0.09% | cBioPortal, TCGA Pan-Cancer Atlas |
| CDH1 p.D254Y | BRCA | DriverHotspot | 0.09% | cBioPortal, TCGA Pan-Cancer Atlas |
| CDH1 p.R335* | BRCA | DriverHotspot | 0.09% | cBioPortal, TCGA Pan-Cancer Atlas |
| CDH1 p.Q23* | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CDH1 p.D254E | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CDH1 p.D254Y | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CDH1 p.D254N | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CDH1 p.X278sp | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CDH1 p.X177sp | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CDH1 p.X440sp | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CDH1 p.D288V | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CDH1 p.D288N | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CDH1 p.X722sp | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CDH1 p.R335Q | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CDH1 p.R335* | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CDH1 p.R63P | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CDH1 p.R63G | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CDH1 p.R63* | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CDH1 p.Y190C | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CDH1 p.Leu711Val | UNSPEC | VUS | Not reported | ClinVar |
| CDH1 p.Leu711Val | UNSPEC | VUS | Not reported | ClinVar |
| CDH1 p.Ala617Thr | UNSPEC | VUS | Not reported | ClinVar |