Gene dossier

CHEK2

2,226 mutation records across 8 cancer labels and 4 source families.

0 actionable6 hotspotsTP53

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
CHEK2 p.E70G substitution	CHOL	Likely Driver	2.8%	cBioPortal, TCGA Pan-Cancer Atlas
CHEK2 p.A98Mfs*13 frameshift	DLBCLNOS	Likely Driver	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
CHEK2 p.X420_splice splice	UCS	Likely Driver	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
CHEK2 p.L338R substitution	UCS	Likely Driver	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
CHEK2 p.R406H substitution	CHRCC	Likely Driver	1.5%	cBioPortal, TCGA Pan-Cancer Atlas
CHEK2 p.N184I substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
CHEK2 p.R95* substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
CHEK2 p.R346H substitution	HGSOC	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
CHEK2 p.R346C substitution	BRCA	DriverHotspot	0.09%	cBioPortal, TCGA Pan-Cancer Atlas
CHEK2 p.R346C substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
CHEK2 p.R346S substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
CHEK2 p.R346G substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
CHEK2 p.R346H substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
CHEK2 p.Ile157Thr substitution	UNSPEC	Driver	Not reported	ClinVar
CHEK2 p.Ile157Thr substitution	UNSPEC	Driver	Not reported	ClinVar
CHEK2 p.Arg145Trp substitution	UNSPEC	Driver	Not reported	ClinVar
CHEK2 p.Arg145Trp substitution	UNSPEC	Driver	Not reported	ClinVar
CHEK2 p.Phe475fs deletion	UNSPEC	Driver	Not reported	ClinVar
CHEK2 p.Phe475fs deletion	UNSPEC	Driver	Not reported	ClinVar
CHEK2 p.Pro85Leu substitution	UNSPEC	VUS	Not reported	ClinVar
CHEK2 p.Pro85Leu substitution	UNSPEC	VUS	Not reported	ClinVar
CHEK2 p.Ala17Ser substitution	UNSPEC	Driver	Not reported	ClinVar
CHEK2 p.Ala17Ser substitution	UNSPEC	Driver	Not reported	ClinVar
CHEK2 p.Arg181Cys substitution	UNSPEC	Driver	Not reported	ClinVar
CHEK2 p.Arg181Cys substitution	UNSPEC	Driver	Not reported	ClinVar
CHEK2 p.Glu239Ter substitution	UNSPEC	Driver	Not reported	ClinVar
CHEK2 p.Glu239Ter substitution	UNSPEC	Driver	Not reported	ClinVar
CHEK2 p.Glu239Lys substitution	UNSPEC	Driver	Not reported	ClinVar
CHEK2 p.Glu239Lys substitution	UNSPEC	Driver	Not reported	ClinVar
CHEK2 p.Ser428Phe substitution	UNSPEC	Driver	Not reported	ClinVar