Gene dossier
CIC
53 mutation records across 10 cancer labels and 4 source families.
0 actionable46 hotspotsNot reported
Top records
Prioritized variant evidence
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| CIC p.R215W | DIFG | DriverHotspot | 1.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.R572W | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.R1470H | PLMESO | Likely Driver | 1.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.V924E | ACC | Likely Driver | 1.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.R202W | DIFG | DriverHotspot | 0.97% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.R201W | DIFG | DriverHotspot | 0.97% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.R1515C | DIFG | DriverHotspot | 0.78% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.R215Q | DIFG | DriverHotspot | 0.78% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.R1512H | DIFG | DriverHotspot | 0.58% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.W238* | DIFG | DriverHotspot | 0.39% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.P203S | DIFG | DriverHotspot | 0.39% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.R1512L | DIFG | DriverHotspot | 0.39% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.R1512C | UCEC | DriverHotspot | 0.39% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.R215W | CESC | DriverHotspot | 0.34% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.R1512H | BLCA | DriverHotspot | 0.24% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.R1515H | DIFG | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.R202Q | DIFG | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.N205S | DIFG | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.S231G | DIFG | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.R1512S | DIFG | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.P203L | DIFG | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.S231I | DIFG | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.R1512H | UCEC | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.R1515C | UCEC | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.R1515H | COADREAD | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.R1512C | BRCA | DriverHotspot | 0.09% | cBioPortal, TCGA Pan-Cancer Atlas |
| CIC p.R215Q | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CIC p.R215R | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CIC p.R215W | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CIC p.R202Q | Not reported | DriverHotspot | Not reported | Cancer Hotspots |