Gene dossier
DIS3
37 mutation records across 13 cancer labels and 4 source families.
0 actionable34 hotspotsNot reported
Top records
Prioritized variant evidence
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| DIS3 p.E336K | CHRCC | Likely Driver | 1.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| DIS3 p.R382Q | COADREAD | DriverHotspot | 0.75% | cBioPortal, TCGA Pan-Cancer Atlas |
| DIS3 p.R382Q | UCEC | DriverHotspot | 0.58% | cBioPortal, TCGA Pan-Cancer Atlas |
| DIS3 p.R689Q | COADREAD | DriverHotspot | 0.56% | cBioPortal, TCGA Pan-Cancer Atlas |
| DIS3 p.D488N | AML | DriverHotspot | 0.50% | cBioPortal, TCGA Pan-Cancer Atlas |
| DIS3 p.R689Q | UCEC | DriverHotspot | 0.39% | cBioPortal, TCGA Pan-Cancer Atlas |
| DIS3 p.L767F | HCC | DriverHotspot | 0.27% | cBioPortal, TCGA Pan-Cancer Atlas |
| DIS3 p.L767F | DIFG | DriverHotspot | 0.25% | cBioPortal, TCGA Pan-Cancer Atlas |
| DIS3 p.L767F | CCRCC | DriverHotspot | 0.25% | cBioPortal, TCGA Pan-Cancer Atlas |
| DIS3 p.R780S | CCRCC | DriverHotspot | 0.25% | cBioPortal, TCGA Pan-Cancer Atlas |
| DIS3 p.L767F | BLCA | DriverHotspot | 0.24% | cBioPortal, TCGA Pan-Cancer Atlas |
| DIS3 p.R382Q | STAD | DriverHotspot | 0.23% | cBioPortal, TCGA Pan-Cancer Atlas |
| DIS3 p.R689G | PRAD | DriverHotspot | 0.20% | cBioPortal, TCGA Pan-Cancer Atlas |
| DIS3 p.D488G | DIFG | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| DIS3 p.D488N | LUAD | DriverHotspot | 0.18% | cBioPortal, TCGA Pan-Cancer Atlas |
| DIS3 p.D488A | LUAD | DriverHotspot | 0.18% | cBioPortal, TCGA Pan-Cancer Atlas |
| DIS3 p.R689Q | BRCA | DriverHotspot | 0.09% | cBioPortal, TCGA Pan-Cancer Atlas |
| DIS3 p.D488A | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| DIS3 p.D488G | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| DIS3 p.D488H | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| DIS3 p.D488Y | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| DIS3 p.D488N | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| DIS3 p.R780S | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| DIS3 p.R780T | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| DIS3 p.R780G | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| DIS3 p.R780K | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| DIS3 p.D479V | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| DIS3 p.D479G | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| DIS3 p.D479H | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| DIS3 p.D479Y | Not reported | DriverHotspot | Not reported | Cancer Hotspots |