Gene dossier

DNMT3A

61 mutation records across 5 cancer labels and 4 source families.

0 actionable8 hotspotsChromatin

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
DNMT3A p.R882H substitution	AML	DriverHotspot	10.5%	cBioPortal, TCGA Pan-Cancer Atlas
DNMT3A p.R882C substitution	AML	DriverHotspot	3.5%	cBioPortal, TCGA Pan-Cancer Atlas
DNMT3A p.Q249* substitution	PLMESO	Likely Driver	1.2%	cBioPortal, TCGA Pan-Cancer Atlas
DNMT3A p.R792C substitution	PLMESO	Likely Driver	1.2%	cBioPortal, TCGA Pan-Cancer Atlas
DNMT3A p.R736H substitution	AML	Likely Driver	1.0%	cBioPortal, TCGA Pan-Cancer Atlas
DNMT3A p.R882P substitution	AML	DriverHotspot	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
DNMT3A p.R882C substitution	LUAD	DriverHotspot	0.18%	cBioPortal, TCGA Pan-Cancer Atlas
DNMT3A p.R882H substitution	BRCA	DriverHotspot	0.09%	cBioPortal, TCGA Pan-Cancer Atlas
DNMT3A p.R882P substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
DNMT3A p.R882C substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
DNMT3A p.R882H substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
DNMT3A p.Gln402Ter substitution	UNSPEC	Driver	Not reported	ClinVar
DNMT3A p.Gln402Ter substitution	UNSPEC	Driver	Not reported	ClinVar
DNMT3A p.Arg635Trp substitution	UNSPEC	Driver	Not reported	ClinVar
DNMT3A p.Arg635Trp substitution	UNSPEC	Driver	Not reported	ClinVar
DNMT3A p.Pro904Leu substitution	UNSPEC	Driver	Not reported	ClinVar
DNMT3A p.Pro904Leu substitution	UNSPEC	Driver	Not reported	ClinVar
DNMT3A p.Arg882His substitution	UNSPEC	Driver	Not reported	ClinVar
DNMT3A p.Arg882His substitution	UNSPEC	Driver	Not reported	ClinVar
DNMT3A p.Arg882Cys substitution	UNSPEC	Driver	Not reported	ClinVar
DNMT3A p.Arg882Cys substitution	UNSPEC	Driver	Not reported	ClinVar
DNMT3A p.Arg771Ter substitution	UNSPEC	Driver	Not reported	ClinVar
DNMT3A p.Arg771Ter substitution	UNSPEC	Driver	Not reported	ClinVar
DNMT3A p.Arg771Gln substitution	UNSPEC	Driver	Not reported	ClinVar
DNMT3A p.Arg771Gln substitution	UNSPEC	Driver	Not reported	ClinVar
DNMT3A p.Gln842Arg substitution	UNSPEC	Driver	Not reported	ClinVar
DNMT3A p.Gln842Arg substitution	UNSPEC	Driver	Not reported	ClinVar
DNMT3A p.Pro307Leu substitution	UNSPEC	Driver	Not reported	ClinVar
DNMT3A p.Pro307Leu substitution	UNSPEC	Driver	Not reported	ClinVar
DNMT3A p.Ala3Ser substitution	UNSPEC	Driver	Not reported	ClinVar