Gene dossier

EGFR

425 mutation records across 11 cancer labels and 4 source families.

425 actionable132 hotspotsRTK-RAS

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
EGFR p.L858R substitution	LUAD	DriverHotspotActionable	4.1%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.E746_A750del deletion	LUAD	DriverHotspotActionable	1.9%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.R222C substitution	DIFG	DriverHotspotActionable	1.5%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.A289T substitution	DIFG	DriverHotspotActionable	1.5%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.A289D substitution	DIFG	DriverHotspotActionable	1.3%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.G598V substitution	DIFG	DriverHotspotActionable	1.2%	TCGA Pan-Cancer Atlas, cBioPortal
EGFR p.A289V substitution	DIFG	DriverHotspotActionable	1.2%	TCGA Pan-Cancer Atlas, cBioPortal
EGFR p.R377K substitution	ACC	Likely DriverActionable	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.V159M substitution	ACC	Likely DriverActionable	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.E746_A750del deletion	LUAD	DriverHotspotActionable	0.88%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.H304Y substitution	DIFG	DriverHotspotActionable	0.76%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.R252C substitution	DIFG	DriverHotspotActionable	0.58%	TCGA Pan-Cancer Atlas, cBioPortal
EGFR p.L62R substitution	DIFG	DriverHotspotActionable	0.58%	TCGA Pan-Cancer Atlas, cBioPortal
EGFR p.G598E substitution	ESCA	DriverHotspotActionable	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.A767_V769dup insertion	HCC	DriverHotspotActionable	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.L861Q substitution	LUAD	DriverHotspotActionable	0.53%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.E709_T710delinsD deletion	LUAD	DriverHotspotActionable	0.53%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.G598A substitution	DIFG	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.T363I substitution	DIFG	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.R252H substitution	STAD	DriverHotspotActionable	0.46%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.L861Q substitution	LUSC	DriverHotspotActionable	0.41%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.R252P substitution	DIFG	DriverHotspotActionable	0.39%	TCGA Pan-Cancer Atlas, cBioPortal
EGFR p.R108K substitution	DIFG	DriverHotspotActionable	0.39%	TCGA Pan-Cancer Atlas, cBioPortal
EGFR p.L62R substitution	LUAD	DriverHotspotActionable	0.35%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.S768I substitution	LUAD	DriverHotspotActionable	0.35%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.T790M substitution	LUAD	DriverHotspotActionable	0.35%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.G719A substitution	LUAD	DriverHotspotActionable	0.35%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.L747_T751del deletion	LUAD	DriverHotspotActionable	0.35%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.P596R substitution	DIFG	DriverHotspotActionable	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
EGFR p.P596S substitution	DIFG	DriverHotspotActionable	0.25%	cBioPortal, TCGA Pan-Cancer Atlas