Gene dossier
FBXW7
202 mutation records across 16 cancer labels and 4 source families.
0 actionable186 hotspotsNOTCH
Top records
Prioritized variant evidence
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| FBXW7 p.R465C | UCS | DriverHotspot | 7.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R479Q | UCS | DriverHotspot | 5.3% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R465H | UCS | DriverHotspot | 3.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R689W | UCS | DriverHotspot | 3.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R505G | UCS | DriverHotspot | 3.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R465H | COADREAD | DriverHotspot | 2.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R465C | STAD | DriverHotspot | 2.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R505G | BLCA | DriverHotspot | 2.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R465H | UCEC | DriverHotspot | 1.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.S396N | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R367* | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.G423V | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.T385I | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.S558F | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.H500R | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.S398F | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R505L | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R658* | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R465P | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R465C | COADREAD | DriverHotspot | 1.7% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R465C | UCEC | DriverHotspot | 1.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R505C | UCEC | DriverHotspot | 1.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R505G | CESC | DriverHotspot | 1.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R689W | UCEC | DriverHotspot | 1.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R479Q | UM | DriverHotspot | 1.3% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R505G | HNSC | DriverHotspot | 1.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R658* | UCEC | DriverHotspot | 1.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.G423V | UCEC | DriverHotspot | 1.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R367* | COADREAD | DriverHotspot | 1.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R505G | ESCA | DriverHotspot | 1.1% | cBioPortal, TCGA Pan-Cancer Atlas |