Gene dossier

FGFR2

58 mutation records across 15 cancer labels and 4 source families.

58 actionable40 hotspotsRTK-RAS

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
FGFR2 p.S252W substitution	UCEC	DriverHotspotActionable	4.6%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.F276C substitution	CHOL	DriverHotspotActionable	2.8%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.Y375C substitution	CHOL	DriverHotspotActionable	2.8%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.W72C substitution	DLBCLNOS	Likely DriverActionable	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.S252W substitution	UCS	DriverHotspotActionable	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.V69M substitution	UCS	Likely DriverActionable	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.R210* substitution	UM	Likely DriverActionable	1.3%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.N549K substitution	UCEC	DriverHotspotActionable	1.2%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.N149D substitution	ACC	Likely DriverActionable	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.C382R substitution	UCEC	DriverHotspotActionable	0.97%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.R203H substitution	UCEC	DriverHotspotActionable	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.N549H substitution	UCEC	DriverHotspotActionable	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.Y375C substitution	UCEC	DriverHotspotActionable	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.Y375C substitution	CESC	DriverHotspotActionable	0.34%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.N549K substitution	BLCA	DriverHotspotActionable	0.24%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.C382R substitution	STAD	DriverHotspotActionable	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.C382R substitution	LUSC	DriverHotspotActionable	0.21%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.N549K substitution	UCEC	DriverHotspotActionable	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.C382Y substitution	UCEC	DriverHotspotActionable	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.P253R substitution	UCEC	DriverHotspotActionable	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.S252W substitution	HGSOC	DriverHotspotActionable	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.P253R substitution	HGSOC	DriverHotspotActionable	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.N549K substitution	BRCA	DriverHotspotActionable	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.R203H substitution	COADREAD	DriverHotspotActionable	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.P253L substitution	COADREAD	DriverHotspotActionable	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.P253L substitution	LUAD	DriverHotspotActionable	0.18%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.N549K substitution	LUAD	DriverHotspotActionable	0.18%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.N549K substitution	BRCA	DriverHotspotActionable	0.09%	cBioPortal, TCGA Pan-Cancer Atlas
FGFR2 p.N549S substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
FGFR2 p.N549T substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots