Gene dossier
FGFR3
53 mutation records across 9 cancer labels and 4 source families.
53 actionable28 hotspotsRTK-RAS
Top records
Prioritized variant evidence
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| FGFR3 p.S249C | BLCA | DriverHotspotActionable | 7.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.Y373C | BLCA | DriverHotspotActionable | 2.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.D758V | UCS | Likely DriverActionable | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.G370C | BLCA | DriverHotspotActionable | 1.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.S400N | PLMESO | Likely DriverActionable | 1.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.S249C | LUSC | DriverHotspotActionable | 0.83% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.S249C | HNSC | DriverHotspotActionable | 0.78% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.R248C | BLCA | DriverHotspotActionable | 0.73% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.Y373C | PRCC | DriverHotspotActionable | 0.72% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.G380R | BLCA | DriverHotspotActionable | 0.49% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.S371C | BLCA | DriverHotspotActionable | 0.49% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.K650E | BLCA | DriverHotspotActionable | 0.49% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.S249C | PRCC | DriverHotspotActionable | 0.36% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.K650N | PRCC | DriverHotspotActionable | 0.36% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.K650E | DIFG | DriverHotspotActionable | 0.25% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.G380R | STAD | DriverHotspotActionable | 0.23% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.G380R | LUSC | DriverHotspotActionable | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.R248C | HNSC | DriverHotspotActionable | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.G380R | HNSC | DriverHotspotActionable | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.S249C | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| FGFR3 p.Y373C | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| FGFR3 p.R248C | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| FGFR3 p.G370C | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| FGFR3 p.K650T | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| FGFR3 p.K650E | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| FGFR3 p.K650M | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| FGFR3 p.K650N | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| FGFR3 p.G380R | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| FGFR3 p.S371C | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| FGFR3 p.L8L | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |