Gene dossier
GNAS
47 mutation records across 14 cancer labels and 4 source families.
0 actionable33 hotspotsNot reported
Top records
Prioritized variant evidence
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| GNAS p.R201C | PAAD | DriverHotspot | 2.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.X239_splice | PLMESO | Likely Driver | 1.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R201H | PAAD | DriverHotspot | 1.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.G304W | ACC | Likely Driver | 1.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R201C | ACC | DriverHotspot | 1.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R201C | HCC | DriverHotspot | 1.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R201H | COADREAD | DriverHotspot | 0.75% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R201H | ESCA | DriverHotspot | 0.55% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R201C | ESCA | DriverHotspot | 0.55% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R160C | ESCA | DriverHotspot | 0.55% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R201H | LUAD | DriverHotspot | 0.53% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R201C | STAD | DriverHotspot | 0.46% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R201H | STAD | DriverHotspot | 0.46% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R201H | CESC | DriverHotspot | 0.34% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R201C | CESC | DriverHotspot | 0.34% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R160C | STAD | DriverHotspot | 0.23% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R201C | SKCM | DriverHotspot | 0.23% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.Q227L | SKCM | DriverHotspot | 0.23% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R160C | LUSC | DriverHotspot | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.Q227H | THPA | DriverHotspot | 0.20% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R201L | COADREAD | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R201C | COADREAD | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R201C | LUAD | DriverHotspot | 0.18% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R160C | LUAD | DriverHotspot | 0.18% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R201C | BRCA | DriverHotspot | 0.09% | cBioPortal, TCGA Pan-Cancer Atlas |
| GNAS p.R201C | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| GNAS p.R201S | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| GNAS p.R201H | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| GNAS p.R201L | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| GNAS p.Q227H | Not reported | DriverHotspot | Not reported | Cancer Hotspots |