Gene dossier

KEAP1

63 mutation records across 7 cancer labels and 3 source families.

0 actionable59 hotspotsNot reported

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
KEAP1 p.Y300_L301del deletion	CHOL	Likely Driver	2.8%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.A95V substitution	CHOL	Likely Driver	2.8%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.L153V substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.V465M substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.V155F substitution	LUSC	DriverHotspot	0.41%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.R470C substitution	LUSC	DriverHotspot	0.41%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.R320Q substitution	LUSC	DriverHotspot	0.41%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.G333S substitution	LUAD	DriverHotspot	0.35%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.G417V substitution	LUAD	DriverHotspot	0.35%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.G480W substitution	LUAD	DriverHotspot	0.35%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.R470C substitution	SKCM	DriverHotspot	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.G480W substitution	SKCM	DriverHotspot	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.R320L substitution	LUSC	DriverHotspot	0.21%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.R272L substitution	LUSC	DriverHotspot	0.21%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.G333C substitution	LUSC	DriverHotspot	0.21%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.G480W substitution	LUSC	DriverHotspot	0.21%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.R272C substitution	HNSC	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.R470C substitution	HNSC	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.R470H substitution	HNSC	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.R272C substitution	UCEC	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.R601L substitution	UCEC	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.R260L substitution	LUAD	DriverHotspot	0.18%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.V155A substitution	LUAD	DriverHotspot	0.18%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.M110V substitution	LUAD	DriverHotspot	0.18%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.R470C substitution	LUAD	DriverHotspot	0.18%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.R470S substitution	LUAD	DriverHotspot	0.18%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.V155F substitution	LUAD	DriverHotspot	0.18%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.G417R substitution	LUAD	DriverHotspot	0.18%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.G417W substitution	LUAD	DriverHotspot	0.18%	cBioPortal, TCGA Pan-Cancer Atlas
KEAP1 p.G417E substitution	LUAD	DriverHotspot	0.18%	cBioPortal, TCGA Pan-Cancer Atlas