Gene dossier

MEN1

659 mutation records across 5 cancer labels and 3 source families.

0 actionable0 hotspotsNot reported

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
MEN1 p.P475L substitution	UCS	Likely Driver	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
MEN1 p.R234H substitution	UM	Likely Driver	1.3%	cBioPortal, TCGA Pan-Cancer Atlas
MEN1 p.R521Gfs*43 frameshift	STAD	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
MEN1 p.X267_splice splice	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
MEN1 p.E364Vfs*6 frameshift	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
MEN1 p.Y317* substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
MEN1 p.R420* substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
MEN1 p.R521Pfs*15 frameshift	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
MEN1 p.I85Sfs*33 frameshift	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
MEN1 p.W270* substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
MEN1 p.Phe134fs deletion	UNSPEC	Driver	Not reported	ClinVar
MEN1 p.Phe134fs deletion	UNSPEC	Driver	Not reported	ClinVar
MEN1 p.Trp198Ter substitution	UNSPEC	Driver	Not reported	ClinVar
MEN1 p.Trp198Ter substitution	UNSPEC	Driver	Not reported	ClinVar
MEN1 p.Glu363del deletion	UNSPEC	Driver	Not reported	ClinVar
MEN1 p.Glu363del deletion	UNSPEC	Driver	Not reported	ClinVar
MEN1 p.Trp436Arg substitution	UNSPEC	Driver	Not reported	ClinVar
MEN1 p.Trp436Arg substitution	UNSPEC	Driver	Not reported	ClinVar
MEN1 p.Arg527Ter substitution	UNSPEC	Driver	Not reported	ClinVar
MEN1 p.Arg527Ter substitution	UNSPEC	Driver	Not reported	ClinVar
MEN1 p.Gln260Ter substitution	UNSPEC	Driver	Not reported	ClinVar
MEN1 p.Gln260Ter substitution	UNSPEC	Driver	Not reported	ClinVar
MEN1 p.Arg460Ter substitution	UNSPEC	Driver	Not reported	ClinVar
MEN1 p.Arg460Ter substitution	UNSPEC	Driver	Not reported	ClinVar
MEN1 p.Ile85fs deletion	UNSPEC	Driver	Not reported	ClinVar
MEN1 p.Ile85fs deletion	UNSPEC	Driver	Not reported	ClinVar
MEN1 p.His139Asp substitution	UNSPEC	Driver	Not reported	ClinVar
MEN1 p.His139Asp substitution	UNSPEC	Driver	Not reported	ClinVar
MEN1 p.Asp418Asn substitution	UNSPEC	Driver	Not reported	ClinVar
MEN1 p.Asp418Asn substitution	UNSPEC	Driver	Not reported	ClinVar