Gene dossier

NF1

3,554 mutation records across 13 cancer labels and 4 source families.

0 actionable28 hotspotsRTK-RAS

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
NF1 p.H1962Pfs*2 frameshift	DLBCLNOS	Likely Driver	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.N401K substitution	DLBCLNOS	Likely Driver	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.R2450* substitution	UCEC	DriverHotspot	1.9%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.L2604I substitution	UCS	Likely Driver	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.T2741R substitution	UCS	Likely Driver	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.V2799I substitution	UCS	Likely Driver	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.Q400* substitution	UCS	Likely Driver	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.C1682R substitution	CHRCC	Likely Driver	1.5%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.R1362* substitution	UCEC	Likely Driver	1.4%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.R440* substitution	SKCM	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.Q1235* substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.E2155* substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.X775_splice splice	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.R1970Efs*9 frameshift	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.L356Q substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.Q2002* substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.R1276Q substitution	AML	Likely Driver	1.0%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.R1241* substitution	AML	DriverHotspot	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.R1870Q substitution	SKCM	DriverHotspot	0.45%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.R2450* substitution	DIFG	DriverHotspot	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.R461* substitution	UCEC	DriverHotspot	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.R440Q substitution	COADREAD	DriverHotspot	0.37%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.R2450* substitution	CESC	DriverHotspot	0.34%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.R461* substitution	DIFG	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.R2450Q substitution	BLCA	DriverHotspot	0.24%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.R461* substitution	STAD	DriverHotspot	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.R1870Q substitution	STAD	DriverHotspot	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.R1241* substitution	SKCM	DriverHotspot	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.R1870Q substitution	DIFG	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
NF1 p.R461Q substitution	UCEC	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas