Gene dossier
NOTCH1
49 mutation records across 10 cancer labels and 4 source families.
0 actionable31 hotspotsNOTCH
Top records
Prioritized variant evidence
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| NOTCH1 p.A1640T | CHOL | Likely Driver | 2.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| NOTCH1 p.C1345* | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| NOTCH1 p.S385F | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| NOTCH1 p.A1906T | CHRCC | Likely Driver | 1.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| NOTCH1 p.F357del | DIFG | DriverHotspot | 1.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| NOTCH1 p.E455K | HNSC | DriverHotspot | 0.58% | cBioPortal, TCGA Pan-Cancer Atlas |
| NOTCH1 p.R365C | ESCA | DriverHotspot | 0.55% | cBioPortal, TCGA Pan-Cancer Atlas |
| NOTCH1 p.D338del | DIFG | DriverHotspot | 0.39% | cBioPortal, TCGA Pan-Cancer Atlas |
| NOTCH1 p.I471T | STAD | DriverHotspot | 0.23% | cBioPortal, TCGA Pan-Cancer Atlas |
| NOTCH1 p.C440S | DIFG | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| NOTCH1 p.Y358del | DIFG | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| NOTCH1 p.S356del | DIFG | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| NOTCH1 p.F357del | HNSC | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| NOTCH1 p.C440F | HNSC | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| NOTCH1 p.C440R | HNSC | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| NOTCH1 p.F357del | UCEC | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| NOTCH1 p.E455K | LUAD | DriverHotspot | 0.18% | cBioPortal, TCGA Pan-Cancer Atlas |
| NOTCH1 p.F853C | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| NOTCH1 p.F853I | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| NOTCH1 p.R365C | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| NOTCH1 p.R365S | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| NOTCH1 p.C440R | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| NOTCH1 p.C440S | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| NOTCH1 p.C440F | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| NOTCH1 p.C440W | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| NOTCH1 p.G310R | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| NOTCH1 p.G310E | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| NOTCH1 p.E455E | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| NOTCH1 p.E455K | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| NOTCH1 p.I471T | Not reported | DriverHotspot | Not reported | Cancer Hotspots |