Gene dossier

NSD1

36 mutation records across 7 cancer labels and 4 source families.

0 actionable6 hotspotsNot reported

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
NSD1 p.M1531Cfs*43 frameshift	UCEC	Likely Driver	2.3%	cBioPortal, TCGA Pan-Cancer Atlas
NSD1 p.R1778* substitution	UCS	Likely Driver	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
NSD1 p.A2270E substitution	UCS	Likely Driver	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
NSD1 p.A1260V substitution	UCS	Likely Driver	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
NSD1 p.I1336M substitution	UCS	Likely Driver	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
NSD1 p.K1530T substitution	UCS	Likely Driver	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
NSD1 p.T725M substitution	UM	Likely Driver	1.3%	cBioPortal, TCGA Pan-Cancer Atlas
NSD1 p.Q2447H substitution	PLMESO	Likely Driver	1.2%	cBioPortal, TCGA Pan-Cancer Atlas
NSD1 p.R1074C substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
NSD1 p.R1700* substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
NSD1 p.C1710S substitution	HNSC	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
NSD1 p.C1710Y substitution	HNSC	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
NSD1 p.F392F substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
NSD1 p.C1710S substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
NSD1 p.C1710Y substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
NSD1 p.C1710* substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
NSD1 p.Ser437Ter substitution	UNSPEC	Driver	Not reported	ClinVar
NSD1 p.Ser437Ter substitution	UNSPEC	Driver	Not reported	ClinVar
NSD1 c.6463+1G>A substitution	UNSPEC	Driver	Not reported	ClinVar
NSD1 c.6463+1G>A substitution	UNSPEC	Driver	Not reported	ClinVar
NSD1 p.Arg604Ter substitution	UNSPEC	Driver	Not reported	ClinVar
NSD1 p.Arg604Ter substitution	UNSPEC	Driver	Not reported	ClinVar
NSD1 c.4378+1G>A substitution	UNSPEC	Driver	Not reported	ClinVar
NSD1 c.4378+1G>A substitution	UNSPEC	Driver	Not reported	ClinVar
NSD1 p.Gln1989Ter substitution	UNSPEC	Driver	Not reported	ClinVar
NSD1 p.Gln1989Ter substitution	UNSPEC	Driver	Not reported	ClinVar
NSD1 p.Arg1778Ter substitution	UNSPEC	Driver	Not reported	ClinVar
NSD1 p.Arg1778Ter substitution	UNSPEC	Driver	Not reported	ClinVar
NSD1 p.Arg788Ter substitution	UNSPEC	Driver	Not reported	ClinVar
NSD1 p.Arg788Ter substitution	UNSPEC	Driver	Not reported	ClinVar