Gene dossier

PBRM1

38 mutation records across 15 cancer labels and 4 source families.

0 actionable23 hotspotsNot reported

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
PBRM1 p.R534* substitution	CHOL	Likely Driver	2.8%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.V992_F993insL insertion	CHOL	Likely Driver	2.8%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.E588* substitution	CHOL	Likely Driver	2.8%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.R490* substitution	CHOL	Likely Driver	2.8%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.R74Sfs*18 frameshift	CHOL	Likely Driver	2.8%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.K277* substitution	CHOL	Likely Driver	2.8%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.R472* substitution	CHOL	Likely Driver	2.8%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.Y54C substitution	DLBCLNOS	Likely Driver	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.E160K substitution	UCS	Likely Driver	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.R1160* substitution	UCS	DriverHotspot	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.R710* substitution	UCS	DriverHotspot	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.Q422* substitution	PLMESO	Likely Driver	1.2%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.G1455Efs*34 frameshift	PLMESO	Likely Driver	1.2%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.A749S substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.L919Q substitution	AML	Likely Driver	1.0%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.R710* substitution	UCEC	DriverHotspot	0.77%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.R1160* substitution	UCEC	DriverHotspot	0.58%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.R1160* substitution	STAD	DriverHotspot	0.46%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.R710* substitution	PRCC	DriverHotspot	0.36%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.R710* substitution	DIFG	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.R710* substitution	CCRCC	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.R1160* substitution	CCRCC	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.R921* substitution	CCRCC	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.R1160* substitution	SKCM	DriverHotspot	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.R710* substitution	SKCM	DriverHotspot	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.R921* substitution	DIFG	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.R921* substitution	HNSC	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.R921* substitution	UCEC	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.R1160* substitution	COADREAD	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
PBRM1 p.R1160P substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots