Gene dossier

PDGFRA

62 mutation records across 5 cancer labels and 4 source families.

62 actionable20 hotspotsRTK-RAS

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
PDGFRA p.V859M substitution	UM	Likely DriverActionable	1.3%	cBioPortal, TCGA Pan-Cancer Atlas
PDGFRA p.Y872D substitution	ACC	Likely DriverActionable	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
PDGFRA p.E229K substitution	DIFG	DriverHotspotActionable	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
PDGFRA p.C235R substitution	DIFG	DriverHotspotActionable	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
PDGFRA p.N659K substitution	DIFG	DriverHotspotActionable	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
PDGFRA p.C235S substitution	SKCM	DriverHotspotActionable	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
PDGFRA p.E229K substitution	SKCM	DriverHotspotActionable	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
PDGFRA p.C235Y substitution	DIFG	DriverHotspotActionable	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
PDGFRA p.E229V substitution	DIFG	DriverHotspotActionable	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
PDGFRA p.D842D substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
PDGFRA p.D842V substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
PDGFRA p.D842H substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
PDGFRA p.D842I substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
PDGFRA p.E229V substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
PDGFRA p.E229* substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
PDGFRA p.E229K substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
PDGFRA p.N659S substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
PDGFRA p.N659Y substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
PDGFRA p.N659K substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
PDGFRA p.C235R substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
PDGFRA p.C235S substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
PDGFRA p.C235Y substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
PDGFRA p.Asp842Val substitution	UNSPEC	DriverActionable	Not reported	ClinVar
PDGFRA p.Asp842Val substitution	UNSPEC	DriverActionable	Not reported	ClinVar
PDGFRA p.Ile843_Asp846del deletion	UNSPEC	DriverActionable	Not reported	ClinVar
PDGFRA p.Ile843_Asp846del deletion	UNSPEC	DriverActionable	Not reported	ClinVar
PDGFRA p.His845_Asn848del deletion	UNSPEC	DriverActionable	Not reported	ClinVar
PDGFRA p.His845_Asn848del deletion	UNSPEC	DriverActionable	Not reported	ClinVar
PDGFRA p.Val561Asp substitution	UNSPEC	DriverActionable	Not reported	ClinVar
PDGFRA p.Val561Asp substitution	UNSPEC	DriverActionable	Not reported	ClinVar