Gene dossier
PIK3R1
239 mutation records across 15 cancer labels and 4 source families.
0 actionable211 hotspotsPI3K-AKT
Top records
Prioritized variant evidence
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| PIK3R1 p.R348* | UCEC | DriverHotspot | 2.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.G27C | CHOL | Likely Driver | 2.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.L149P | CHOL | Likely Driver | 2.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.E635* | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.G376R | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.Q221Pfs*8 | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.L420Ffs*22 | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.N453_Y463del | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.H450_E451insD | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.K448_N453del | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.L466_E469del | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.S102L | CHRCC | Likely Driver | 1.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.N564D | UCEC | DriverHotspot | 1.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.R461* | UCEC | Likely Driver | 1.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.R642* | UCEC | VUS | 0.97% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.T576del | UCEC | DriverHotspot | 0.97% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.R348* | COADREAD | DriverHotspot | 0.75% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.N564D | DIFG | DriverHotspot | 0.58% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.K567E | UCEC | DriverHotspot | 0.58% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.G376R | UCEC | DriverHotspot | 0.58% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.R577del | ESCA | DriverHotspot | 0.55% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.K379N | DIFG | DriverHotspot | 0.50% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.G376R | DIFG | DriverHotspot | 0.39% | TCGA Pan-Cancer Atlas, cBioPortal |
| PIK3R1 p.D464_Y467del | DIFG | DriverHotspot | 0.39% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.E451_Y452del | UCEC | DriverHotspot | 0.39% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.K575_R577del | UCEC | DriverHotspot | 0.39% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.Y580_L581insF | CESC | DriverHotspot | 0.34% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.K567_L570del | BRCA | DriverHotspot | 0.28% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.R574del | HCC | DriverHotspot | 0.27% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3R1 p.G376R | DIFG | DriverHotspot | 0.25% | cBioPortal, TCGA Pan-Cancer Atlas |