Gene dossier
POLE
543 mutation records across 14 cancer labels and 4 source families.
0 actionable20 hotspotsDNA Repair
Top records
Prioritized variant evidence
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| POLE p.P286R | UCEC | DriverHotspot | 3.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| POLE p.V2133L | CHOL | Likely Driver | 2.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| POLE p.V411L | UCEC | DriverHotspot | 2.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| POLE p.P286R | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| POLE p.V437M | CHRCC | Likely Driver | 1.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| POLE p.G1065V | PLMESO | Likely Driver | 1.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| POLE p.T457M | ACC | Likely Driver | 1.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| POLE p.T457R | ACC | Likely Driver | 1.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| POLE p.V411L | COADREAD | DriverHotspot | 0.75% | cBioPortal, TCGA Pan-Cancer Atlas |
| POLE p.P286R | PAAD | DriverHotspot | 0.56% | cBioPortal, TCGA Pan-Cancer Atlas |
| POLE p.V411L | UCEC | DriverHotspot | 0.39% | cBioPortal, TCGA Pan-Cancer Atlas |
| POLE p.P286R | COADREAD | DriverHotspot | 0.37% | cBioPortal, TCGA Pan-Cancer Atlas |
| POLE p.V411L | CESC | DriverHotspot | 0.34% | cBioPortal, TCGA Pan-Cancer Atlas |
| POLE p.V411L | DIFG | DriverHotspot | 0.25% | cBioPortal, TCGA Pan-Cancer Atlas |
| POLE p.P286R | BLCA | DriverHotspot | 0.24% | cBioPortal, TCGA Pan-Cancer Atlas |
| POLE p.V411L | STAD | DriverHotspot | 0.23% | cBioPortal, TCGA Pan-Cancer Atlas |
| POLE p.P286L | STAD | DriverHotspot | 0.23% | cBioPortal, TCGA Pan-Cancer Atlas |
| POLE p.P286R | BRCA | DriverHotspot | 0.09% | cBioPortal, TCGA Pan-Cancer Atlas |
| POLE p.P286R | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| POLE p.P286S | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| POLE p.P286T | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| POLE p.P286H | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| POLE p.P286L | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| POLE p.V411L | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| POLE p.E18K | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| POLE p.Leu424Val | UNSPEC | Driver | Not reported | ClinVar |
| POLE p.Leu424Val | UNSPEC | Driver | Not reported | ClinVar |
| POLE c.4444+3A>G | UNSPEC | Driver | Not reported | ClinVar |
| POLE c.4444+3A>G | UNSPEC | Driver | Not reported | ClinVar |
| POLE p.Ser314Ter | UNSPEC | Driver | Not reported | ClinVar |