Gene dossier
PTEN
2,471 mutation records across 22 cancer labels and 4 source families.
0 actionable340 hotspotsPI3K-AKT
Top records
Prioritized variant evidence
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| PTEN p.R130G | UCEC | DriverHotspot | 7.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.R130Q | UCEC | DriverHotspot | 6.6% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.R233* | UCEC | DriverHotspot | 4.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.L320* | CHOL | DriverHotspot | 2.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.T319* | UCEC | Likely Driver | 2.7% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.R335* | DLBCLNOS | DriverHotspot | 2.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.R130* | UCEC | DriverHotspot | 2.3% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.K267Rfs*9 | STAD | Likely Driver | 2.3% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.N323Kfs*2 | UCEC | Likely Driver | 2.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.R142W | UCEC | Likely Driver | 1.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.E7* | UCEC | Likely Driver | 1.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.X342_splice | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.Y155C | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.R130G | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.G132S | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.R234Pfs*9 | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.R130* | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.R233* | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.E201* | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.F341C | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.R130Q | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.A126D | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.D24H | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.D92E | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.P38L | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.N311Mfs*6 | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.Q17* | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.D268Gfs*30 | UCEC | Likely Driver | 1.7% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.E299* | UCEC | Likely Driver | 1.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTEN p.F195S | CHRCC | Likely Driver | 1.5% | cBioPortal, TCGA Pan-Cancer Atlas |