Gene dossier
PTPN11
201 mutation records across 12 cancer labels and 4 source families.
0 actionable56 hotspotsNot reported
Top records
Prioritized variant evidence
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| PTPN11 p.E225D | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.D241G | ACC | Likely Driver | 1.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.F71L | AML | Likely Driver | 1.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.G503V | COADREAD | DriverHotspot | 0.56% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.D61N | AML | DriverHotspot | 0.50% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.Q510L | AML | DriverHotspot | 0.50% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.A72V | AML | DriverHotspot | 0.50% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.Q510H | AML | DriverHotspot | 0.50% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.T468M | STAD | DriverHotspot | 0.46% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.G503V | STAD | DriverHotspot | 0.46% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.T468M | SKCM | DriverHotspot | 0.45% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.Q510L | SOFT_TISSUE | DriverHotspot | 0.39% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.A72D | DIFG | DriverHotspot | 0.39% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.A461T | UCEC | DriverHotspot | 0.39% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.Q510L | DIFG | DriverHotspot | 0.25% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.N308S | DIFG | DriverHotspot | 0.25% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.T507K | DIFG | DriverHotspot | 0.25% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.Q510H | DIFG | DriverHotspot | 0.25% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.A72V | DIFG | DriverHotspot | 0.25% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.F285S | DIFG | DriverHotspot | 0.25% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.E69K | DIFG | DriverHotspot | 0.25% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.E76A | DIFG | DriverHotspot | 0.25% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.A461T | SKCM | DriverHotspot | 0.23% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.Q510H | SKCM | DriverHotspot | 0.23% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.E76K | LUSC | DriverHotspot | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.G503V | LUSC | DriverHotspot | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.N308D | DIFG | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.A461G | UCEC | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.E69D | COADREAD | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| PTPN11 p.E69K | COADREAD | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |