Gene dossier
RB1
675 mutation records across 18 cancer labels and 4 source families.
0 actionable58 hotspotsCell Cycle
Top records
Prioritized variant evidence
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| RB1 p.T726_Y728del | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.X46_splice | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.L688R | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.E280* | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.E545* | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.E97* | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.Q685Sfs*11 | CHRCC | Likely Driver | 1.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.L779Yfs*28 | CHRCC | Likely Driver | 1.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.I285Mfs*4 | PLMESO | Likely Driver | 1.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.E458* | ACC | Likely Driver | 1.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.Q217* | ACC | Likely Driver | 1.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.R445* | DIFG | DriverHotspot | 0.76% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.R552* | ESCA | DriverHotspot | 0.55% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.R579* | SKCM | DriverHotspot | 0.45% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.R445* | SOFT_TISSUE | DriverHotspot | 0.39% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.R787* | SOFT_TISSUE | DriverHotspot | 0.39% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.R552* | SOFT_TISSUE | DriverHotspot | 0.39% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.R552* | DIFG | DriverHotspot | 0.25% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.R552* | BLCA | DriverHotspot | 0.24% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.R251* | BLCA | DriverHotspot | 0.24% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.R320* | BLCA | DriverHotspot | 0.24% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.R455* | BLCA | DriverHotspot | 0.24% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.R445* | BLCA | DriverHotspot | 0.24% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.R552* | STAD | DriverHotspot | 0.23% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.R320* | STAD | DriverHotspot | 0.23% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.R455* | SKCM | DriverHotspot | 0.23% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.R787* | LUSC | DriverHotspot | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.R320* | LUSC | DriverHotspot | 0.21% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.R320* | HNSC | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |
| RB1 p.R251* | HNSC | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |