Gene dossier

RET

206 mutation records across 5 cancer labels and 4 source families.

206 actionable2 hotspotsRTK-RAS

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
RET p.A294V substitution	CHOL	Likely DriverActionable	2.8%	cBioPortal, TCGA Pan-Cancer Atlas
RET p.M918T substitution	SOFT_TISSUE	DriverHotspotActionable	2.2%	cBioPortal, TCGA Pan-Cancer Atlas
RET p.R177Q substitution	UM	Likely DriverActionable	1.3%	cBioPortal, TCGA Pan-Cancer Atlas
RET p.V425A substitution	ACC	Likely DriverActionable	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
RET p.G597V substitution	ACC	Likely DriverActionable	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
RET p.M918T substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
RET p.Cys618Gly substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Cys618Gly substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Cys634Gly substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Cys634Gly substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Cys634Tyr substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Cys634Tyr substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Cys634Ser substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Cys634Ser substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Cys634Phe substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Cys634Phe substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Cys618Ser substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Cys618Ser substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Cys620Arg substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Cys620Arg substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Cys620Tyr substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Cys620Tyr substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Cys634Arg substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Cys634Arg substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Cys634Trp substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Cys634Trp substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Met918Thr substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Met918Thr substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Arg972Gly substitution	UNSPEC	DriverActionable	Not reported	ClinVar
RET p.Arg972Gly substitution	UNSPEC	DriverActionable	Not reported	ClinVar