Gene dossier

RUNX1

503 mutation records across 7 cancer labels and 4 source families.

0 actionable13 hotspotsNot reported

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
RUNX1 p.R201* substitution	AML	DriverHotspot	2.0%	cBioPortal, TCGA Pan-Cancer Atlas
RUNX1 p.T300M substitution	UM	Likely Driver	1.3%	cBioPortal, TCGA Pan-Cancer Atlas
RUNX1 p.F97L substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
RUNX1 p.R162G substitution	AML	DriverHotspot	1.0%	cBioPortal, TCGA Pan-Cancer Atlas
RUNX1 p.R162K substitution	AML	DriverHotspot	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
RUNX1 p.R162S substitution	AML	DriverHotspot	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
RUNX1 p.R201Q substitution	AML	DriverHotspot	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
RUNX1 p.D123Gfs*15 frameshift	BRCA	VUS	0.47%	cBioPortal, TCGA Pan-Cancer Atlas
RUNX1 p.R201G substitution	COADREAD	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
RUNX1 p.R201Q substitution	LUAD	DriverHotspot	0.18%	cBioPortal, TCGA Pan-Cancer Atlas
RUNX1 p.R201Q substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
RUNX1 p.R201G substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
RUNX1 p.R201* substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
RUNX1 p.R162S substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
RUNX1 p.R162G substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
RUNX1 p.R162K substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
RUNX1 c.352-1G>T substitution	UNSPEC	Driver	Not reported	ClinVar
RUNX1 c.352-1G>T substitution	UNSPEC	Driver	Not reported	ClinVar
RUNX1 p.Arg201Gln substitution	UNSPEC	Driver	Not reported	ClinVar
RUNX1 p.Arg201Gln substitution	UNSPEC	Driver	Not reported	ClinVar
RUNX1 p.Lys110Glu substitution	UNSPEC	Driver	Not reported	ClinVar
RUNX1 p.Lys110Glu substitution	UNSPEC	Driver	Not reported	ClinVar
RUNX1 c.508+3del deletion	UNSPEC	Driver	Not reported	ClinVar
RUNX1 c.508+3del deletion	UNSPEC	Driver	Not reported	ClinVar
RUNX1 p.Tyr287Ter substitution	UNSPEC	Driver	Not reported	ClinVar
RUNX1 p.Tyr287Ter substitution	UNSPEC	Driver	Not reported	ClinVar
RUNX1 p.Ala134Pro substitution	UNSPEC	Driver	Not reported	ClinVar
RUNX1 p.Ala134Pro substitution	UNSPEC	Driver	Not reported	ClinVar
RUNX1 p.His85Asn substitution	UNSPEC	VUS	Not reported	ClinVar
RUNX1 p.His85Asn substitution	UNSPEC	VUS	Not reported	ClinVar