Gene dossier

SDHA

709 mutation records across 4 cancer labels and 4 source families.

0 actionable5 hotspotsNot reported

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
SDHA p.X555_splice splice	UCS	Likely Driver	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
SDHA p.P643A substitution	CHRCC	Likely Driver	1.5%	cBioPortal, TCGA Pan-Cancer Atlas
SDHA p.I383F substitution	CHRCC	Likely Driver	1.5%	cBioPortal, TCGA Pan-Cancer Atlas
SDHA p.G434D substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
SDHA p.L639V substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SDHA p.S445S substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SDHA p.S445L substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SDHA p.V644L substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SDHA p.V644M substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SDHA p.Arg554Trp substitution	UNSPEC	Driver	Not reported	ClinVar
SDHA p.Arg554Trp substitution	UNSPEC	Driver	Not reported	ClinVar
SDHA p.Ala524Val substitution	UNSPEC	Driver	Not reported	ClinVar
SDHA p.Ala524Val substitution	UNSPEC	Driver	Not reported	ClinVar
SDHA p.Met1Leu substitution	UNSPEC	Driver	Not reported	ClinVar
SDHA p.Met1Leu substitution	UNSPEC	Driver	Not reported	ClinVar
SDHA p.Gly555Glu substitution	UNSPEC	Driver	Not reported	ClinVar
SDHA p.Gly555Glu substitution	UNSPEC	Driver	Not reported	ClinVar
SDHA p.Arg589Trp substitution	UNSPEC	Driver	Not reported	ClinVar
SDHA p.Arg589Trp substitution	UNSPEC	Driver	Not reported	ClinVar
SDHA p.Thr508Ile substitution	UNSPEC	Driver	Not reported	ClinVar
SDHA p.Thr508Ile substitution	UNSPEC	Driver	Not reported	ClinVar
SDHA p.Ser509Leu substitution	UNSPEC	VUS	Not reported	ClinVar
SDHA p.Ser509Leu substitution	UNSPEC	VUS	Not reported	ClinVar
SDHA p.Thr273Ile substitution	UNSPEC	Driver	Not reported	ClinVar
SDHA p.Thr273Ile substitution	UNSPEC	Driver	Not reported	ClinVar
SDHA p.Arg171His substitution	UNSPEC	Driver	Not reported	ClinVar
SDHA p.Arg171His substitution	UNSPEC	Driver	Not reported	ClinVar
SDHA p.Asp223fs deletion	UNSPEC	Driver	Not reported	ClinVar
SDHA p.Asp223fs deletion	UNSPEC	Driver	Not reported	ClinVar
SDHA p.Arg31Ter substitution	UNSPEC	Driver	Not reported	ClinVar