Gene dossier

SF3B1

85 mutation records across 19 cancer labels and 4 source families.

0 actionable71 hotspotsSplicing

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
SF3B1 p.R625H substitution	UM	DriverHotspot	10.0%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.R625C substitution	UM	DriverHotspot	7.5%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.G740E substitution	CHOL	DriverHotspot	2.8%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.K666T substitution	UM	DriverHotspot	2.5%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.D102A substitution	UCS	Likely Driver	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.K700E substitution	THYM	DriverHotspot	1.6%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.X833_splice splice	AML	Likely Driver	1.5%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.L833F substitution	AML	Likely Driver	1.5%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.E902K substitution	BLCA	DriverHotspot	1.5%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.T663P substitution	UM	Likely Driver	1.3%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.H662R substitution	UM	Likely Driver	1.3%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.G742D substitution	PLMESO	DriverHotspot	1.2%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.R625H substitution	SKCM	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.V184F substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.M1231T substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.R957Q substitution	UCEC	VUS	0.97%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.K700E substitution	BRCA	DriverHotspot	0.94%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.G740E substitution	PAAD	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.K666T substitution	HCC	DriverHotspot	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.K700E substitution	AML	DriverHotspot	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.R625C substitution	SKCM	DriverHotspot	0.45%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.K700E substitution	SOFT_TISSUE	DriverHotspot	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.K666E substitution	CESC	DriverHotspot	0.34%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.N626H substitution	HCC	DriverHotspot	0.27%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.K741N substitution	HCC	DriverHotspot	0.27%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.K741Q substitution	HCC	DriverHotspot	0.27%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.G742D substitution	CCRCC	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.K741E substitution	CCRCC	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.R625C substitution	BLCA	DriverHotspot	0.24%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.G740E substitution	BLCA	DriverHotspot	0.24%	cBioPortal, TCGA Pan-Cancer Atlas