Gene dossier

SMAD4

474 mutation records across 17 cancer labels and 4 source families.

0 actionable173 hotspotsNot reported

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
SMAD4 p.R361H substitution	COADREAD	DriverHotspot	2.1%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.M4Vfs*9 frameshift	UCS	Likely Driver	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.R361C substitution	PAAD	DriverHotspot	1.7%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.E520* substitution	PAAD	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.G352* substitution	PAAD	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.R445* substitution	ESCA	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.R361C substitution	STAD	DriverHotspot	0.92%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.R361C substitution	COADREAD	DriverHotspot	0.75%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.R361H substitution	CESC	DriverHotspot	0.69%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.D537H substitution	COADREAD	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.D351A substitution	PAAD	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.R361H substitution	PAAD	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.S178* substitution	PAAD	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.G352V substitution	PAAD	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.A118V substitution	PAAD	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.D537H substitution	PAAD	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.G358_D360del deletion	PAAD	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.D355G substitution	PAAD	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.L536P substitution	PAAD	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.R361H substitution	ESCA	DriverHotspot	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.R361C substitution	ESCA	DriverHotspot	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.W524L substitution	ESCA	DriverHotspot	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.G386V substitution	ESCA	DriverHotspot	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.G510* substitution	ESCA	DriverHotspot	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.P356S substitution	ESCA	DriverHotspot	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.S178* substitution	ESCA	DriverHotspot	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.R361H substitution	STAD	DriverHotspot	0.46%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.Y95C substitution	PRCC	DriverHotspot	0.36%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.D493N substitution	LUAD	DriverHotspot	0.35%	cBioPortal, TCGA Pan-Cancer Atlas
SMAD4 p.R445* substitution	CESC	DriverHotspot	0.34%	cBioPortal, TCGA Pan-Cancer Atlas