Gene dossier

SMARCB1

108 mutation records across 10 cancer labels and 4 source families.

0 actionable15 hotspotsChromatin

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
SMARCB1 p.T325P substitution	DLBCLNOS	Likely Driver	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
SMARCB1 p.K364R substitution	CHRCC	Likely Driver	1.5%	cBioPortal, TCGA Pan-Cancer Atlas
SMARCB1 p.T381M substitution	CHRCC	Likely Driver	1.5%	cBioPortal, TCGA Pan-Cancer Atlas
SMARCB1 p.E95K substitution	PLMESO	Likely Driver	1.2%	cBioPortal, TCGA Pan-Cancer Atlas
SMARCB1 p.R374W substitution	PAAD	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
SMARCB1 p.K364del deletion	STAD	DriverHotspot	0.46%	cBioPortal, TCGA Pan-Cancer Atlas
SMARCB1 p.R377H substitution	STAD	DriverHotspot	0.46%	cBioPortal, TCGA Pan-Cancer Atlas
SMARCB1 p.R374W substitution	UCEC	DriverHotspot	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
SMARCB1 p.R374Q substitution	PRCC	DriverHotspot	0.36%	cBioPortal, TCGA Pan-Cancer Atlas
SMARCB1 p.R377C substitution	DIFG	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
SMARCB1 p.R377H substitution	COADREAD	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
SMARCB1 p.R377C substitution	COADREAD	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
SMARCB1 p.R374Q substitution	COADREAD	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
SMARCB1 p.R377C substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SMARCB1 p.R377H substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SMARCB1 p.R377L substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SMARCB1 p.R374Q substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SMARCB1 p.R374W substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SMARCB1 p.K364del inframe	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SMARCB1 p.Gln318fs deletion	UNSPEC	Driver	Not reported	ClinVar
SMARCB1 p.Gln318fs deletion	UNSPEC	Driver	Not reported	ClinVar
SMARCB1 ClinVar:8023 deletion	UNSPEC	Driver	Not reported	ClinVar
SMARCB1 p.Gln198fs deletion	UNSPEC	Driver	Not reported	ClinVar
SMARCB1 p.Gln198fs deletion	UNSPEC	Driver	Not reported	ClinVar
SMARCB1 c.986+1G>A substitution	UNSPEC	Driver	Not reported	ClinVar
SMARCB1 c.986+1G>A substitution	UNSPEC	Driver	Not reported	ClinVar
SMARCB1 p.Gln12Ter substitution	UNSPEC	Driver	Not reported	ClinVar
SMARCB1 p.Gln12Ter substitution	UNSPEC	Driver	Not reported	ClinVar
SMARCB1 c.629-361_795+2103dup duplication	UNSPEC	Driver	Not reported	ClinVar
SMARCB1 c.629-361_795+2103dup duplication	UNSPEC	Driver	Not reported	ClinVar