Gene dossier
SPOP
65 mutation records across 8 cancer labels and 4 source families.
0 actionable52 hotspotsNot reported
Top records
Prioritized variant evidence
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| SPOP p.F102I | DLBCLNOS | DriverHotspot | 2.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.P73R | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.R139G | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.R45W | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.D140Y | UCS | Likely Driver | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.M117V | UCS | DriverHotspot | 1.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.W131G | PRAD | DriverHotspot | 1.6% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.M117V | UCEC | DriverHotspot | 1.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.F133V | PRAD | DriverHotspot | 1.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.E47Q | ACC | Likely Driver | 1.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.F133C | PRAD | DriverHotspot | 0.81% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.F102V | PRAD | DriverHotspot | 0.81% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.F133L | PRAD | DriverHotspot | 0.61% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.F133L | PRAD | DriverHotspot | 0.61% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.Y87S | PRAD | DriverHotspot | 0.40% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.W131R | PRAD | DriverHotspot | 0.40% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.F102C | PRAD | DriverHotspot | 0.40% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.Y87C | PRAD | DriverHotspot | 0.40% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.F102S | PRAD | DriverHotspot | 0.40% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.F133I | PRAD | DriverHotspot | 0.40% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.W131L | PRAD | DriverHotspot | 0.40% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.Y87N | PRAD | DriverHotspot | 0.40% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.M117V | CESC | DriverHotspot | 0.34% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.F133S | PRAD | DriverHotspot | 0.20% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.W131S | PRAD | DriverHotspot | 0.20% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.F133L | PRAD | DriverHotspot | 0.20% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.K129E | PRAD | DriverHotspot | 0.20% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.F125I | PRAD | DriverHotspot | 0.20% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.F125L | PRAD | DriverHotspot | 0.20% | cBioPortal, TCGA Pan-Cancer Atlas |
| SPOP p.W131C | DIFG | DriverHotspot | 0.19% | cBioPortal, TCGA Pan-Cancer Atlas |