Gene dossier

STAT3

36 mutation records across 9 cancer labels and 4 source families.

0 actionable21 hotspotsJAK-STAT

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
STAT3 p.D661V substitution	DLBCLNOS	DriverHotspot	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.Q644R substitution	DLBCLNOS	Likely Driver	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.Y640F substitution	DLBCLNOS	Likely Driver	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.H332Y substitution	DLBCLNOS	Likely Driver	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.E616del deletion	DLBCLNOS	DriverHotspot	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.E616G substitution	DLBCLNOS	Likely Driver	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.S614R substitution	DLBCLNOS	DriverHotspot	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.X184_splice splice	UCS	Likely Driver	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.F384L substitution	UCS	DriverHotspot	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.D661Y substitution	CESC	DriverHotspot	0.34%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.H410R substitution	HCC	DriverHotspot	0.27%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.D661Y substitution	STAD	DriverHotspot	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.E616del deletion	STAD	DriverHotspot	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.D661V substitution	HNSC	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.H410R substitution	LUAD	DriverHotspot	0.18%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.H410R substitution	BRCA	DriverHotspot	0.09%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.F384Y substitution	BRCA	DriverHotspot	0.09%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.H410P substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
STAT3 p.H410R substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
STAT3 p.S614R substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
STAT3 p.F384V substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
STAT3 p.F384Y substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
STAT3 p.F384L substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
STAT3 p.D661V substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
STAT3 p.D661Y substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
STAT3 p.E616del inframe	Not reported	DriverHotspot	Not reported	Cancer Hotspots
STAT3 p.Tyr640Phe substitution	UNSPEC	Driver	Not reported	ClinVar
STAT3 p.Tyr640Phe substitution	UNSPEC	Driver	Not reported	ClinVar
STAT3 p.Thr412Ser substitution	UNSPEC	Driver	Not reported	ClinVar
STAT3 p.Thr412Ser substitution	UNSPEC	Driver	Not reported	ClinVar