Gene dossier

TET2

59 mutation records across 8 cancer labels and 4 source families.

0 actionable4 hotspotsNot reported

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
TET2 p.N1748Tfs*15 frameshift	DLBCLNOS	Likely Driver	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
TET2 p.S315F substitution	DLBCLNOS	Likely Driver	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
TET2 p.K1438* substitution	DLBCLNOS	Likely Driver	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
TET2 p.H724Qfs*27 frameshift	UCS	Likely Driver	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
TET2 p.X1137_splice splice	CHRCC	Likely Driver	1.5%	cBioPortal, TCGA Pan-Cancer Atlas
TET2 p.V1557D substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
TET2 p.R1216* substitution	AML	Likely Driver	1.0%	cBioPortal, TCGA Pan-Cancer Atlas
TET2 p.R550* substitution	AML	DriverHotspot	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
TET2 p.R550* substitution	HNSC	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
TET2 p.R550* substitution	UCEC	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
TET2 p.R550* substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
TET2 p.His1382Arg substitution	UNSPEC	VUS	Not reported	ClinVar
TET2 p.His1382Arg substitution	UNSPEC	VUS	Not reported	ClinVar
TET2 ClinVar:800353 insertion	UNSPEC	Driver	Not reported	ClinVar
TET2 ClinVar:800353\|UNSPEC insertion	UNSPEC	Driver	Not reported	ClinVar
TET2 p.Pro480Ser substitution	UNSPEC	VUS	Not reported	ClinVar
TET2 p.Pro480Ser substitution	UNSPEC	VUS	Not reported	ClinVar
TET2 p.Ile1873Thr substitution	UNSPEC	VUS	Not reported	ClinVar
TET2 p.Ile1873Thr substitution	UNSPEC	VUS	Not reported	ClinVar
TET2 p.Tyr1255Ter substitution	UNSPEC	Driver	Not reported	ClinVar
TET2 p.Tyr1255Ter substitution	UNSPEC	Driver	Not reported	ClinVar
TET2 p.Cys1298fs deletion	UNSPEC	Driver	Not reported	ClinVar
TET2 p.Cys1298fs deletion	UNSPEC	Driver	Not reported	ClinVar
TET2 c.3409+1G>A substitution	UNSPEC	Driver	Not reported	ClinVar
TET2 c.3409+1G>A substitution	UNSPEC	Driver	Not reported	ClinVar
TET2 c.3954+5G>A substitution	UNSPEC	Driver	Not reported	ClinVar
TET2 c.3954+5G>A substitution	UNSPEC	Driver	Not reported	ClinVar
TET2 c.3955-2A>G substitution	UNSPEC	Driver	Not reported	ClinVar
TET2 c.3955-2A>G substitution	UNSPEC	Driver	Not reported	ClinVar
TET2 p.Lys603fs deletion	UNSPEC	Driver	Not reported	ClinVar