Gene dossier

TGFBR2

62 mutation records across 12 cancer labels and 4 source families.

0 actionable22 hotspotsNot reported

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
TGFBR2 p.T99A substitution	CHOL	Likely Driver	2.8%	cBioPortal, TCGA Pan-Cancer Atlas
TGFBR2 p.X113_splice splice	PLMESO	Likely Driver	1.2%	cBioPortal, TCGA Pan-Cancer Atlas
TGFBR2 p.L342F substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
TGFBR2 p.Y306C substitution	ACC	Likely Driver	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
TGFBR2 p.E544K substitution	HNSC	DriverHotspot	0.78%	cBioPortal, TCGA Pan-Cancer Atlas
TGFBR2 p.R553H substitution	PAAD	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
TGFBR2 p.D471N substitution	ESCA	DriverHotspot	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
TGFBR2 p.R553C substitution	HNSC	DriverHotspot	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
TGFBR2 p.D471N substitution	UCEC	DriverHotspot	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
TGFBR2 p.R553H substitution	COADREAD	DriverHotspot	0.37%	cBioPortal, TCGA Pan-Cancer Atlas
TGFBR2 p.D471N substitution	COADREAD	DriverHotspot	0.37%	cBioPortal, TCGA Pan-Cancer Atlas
TGFBR2 p.R553C substitution	COADREAD	DriverHotspot	0.37%	cBioPortal, TCGA Pan-Cancer Atlas
TGFBR2 p.D471N substitution	CESC	DriverHotspot	0.34%	cBioPortal, TCGA Pan-Cancer Atlas
TGFBR2 p.R520* substitution	STAD	DriverHotspot	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
TGFBR2 p.R553H substitution	STAD	DriverHotspot	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
TGFBR2 p.R553C substitution	LUAD	DriverHotspot	0.18%	cBioPortal, TCGA Pan-Cancer Atlas
TGFBR2 p.R553C substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
TGFBR2 p.R553G substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
TGFBR2 p.R553H substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
TGFBR2 p.R553L substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
TGFBR2 p.D471V substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
TGFBR2 p.D471Y substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
TGFBR2 p.D471N substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
TGFBR2 p.E544K substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
TGFBR2 p.R520R substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
TGFBR2 p.R520* substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
TGFBR2 p.Ala535fs Microsatellite	UNSPEC	Driver	Not reported	ClinVar
TGFBR2 p.Ala535fs Microsatellite	UNSPEC	Driver	Not reported	ClinVar
TGFBR2 p.Thr315Met substitution	UNSPEC	VUS	Not reported	ClinVar
TGFBR2 p.Thr315Met substitution	UNSPEC	VUS	Not reported	ClinVar