Gene dossier
TP53
4,128 mutation records across 29 cancer labels and 4 source families.
0 actionable2237 hotspotsTP53
Top records
Prioritized variant evidence
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| TP53 p.R248Q | UCS | DriverHotspot | 10.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R273C | DIFG | DriverHotspot | 10.5% | TCGA Pan-Cancer Atlas, cBioPortal |
| TP53 p.R175H | COADREAD | DriverHotspot | 6.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R175H | ESCA | DriverHotspot | 5.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.S241Y | UCS | DriverHotspot | 5.3% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R273H | UCS | DriverHotspot | 5.3% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R248Q | ESCA | DriverHotspot | 4.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R248Q | BLCA | DriverHotspot | 4.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R282W | COADREAD | DriverHotspot | 3.7% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R175H | UCS | DriverHotspot | 3.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.H179R | UCS | DriverHotspot | 3.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.H193R | UCS | DriverHotspot | 3.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R248Q | COADREAD | DriverHotspot | 3.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R248W | ESCA | DriverHotspot | 3.3% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R273H | ESCA | DriverHotspot | 3.3% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R273H | COADREAD | DriverHotspot | 3.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R213* | CHRCC | DriverHotspot | 3.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R249S | HCC | DriverHotspot | 3.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R280T | BLCA | DriverHotspot | 2.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R158L | LUSC | DriverHotspot | 2.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R175H | HGSOC | DriverHotspot | 2.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R248W | COADREAD | DriverHotspot | 2.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R248W | CHOL | DriverHotspot | 2.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.S241F | CHOL | DriverHotspot | 2.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.C141R | CHOL | DriverHotspot | 2.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.M237Gfs*20 | CHOL | Likely Driver | 2.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.Y234* | CHOL | DriverHotspot | 2.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R175H | STAD | DriverHotspot | 2.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.R282W | ESCA | DriverHotspot | 2.7% | cBioPortal, TCGA Pan-Cancer Atlas |
| TP53 p.E285K | BLCA | DriverHotspot | 2.7% | cBioPortal, TCGA Pan-Cancer Atlas |