Gene dossier
TSC2
475 mutation records across 5 cancer labels and 3 source families.
0 actionable0 hotspotsPI3K-AKT
Top records
Prioritized variant evidence
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| TSC2 p.R917L | CHOL | Likely Driver | 2.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| TSC2 p.I475F | CHRCC | Likely Driver | 1.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| TSC2 p.E1049K | CHRCC | Likely Driver | 1.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| TSC2 p.E1360K | PLMESO | Likely Driver | 1.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| TSC2 p.I1662M | ACC | Likely Driver | 1.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| TSC2 p.Pro1675Leu | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.Pro1675Leu | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.Arg505Ter | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.Arg505Ter | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.Arg611Gln | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.Arg611Gln | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.Gln1503Pro | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.Gln1503Pro | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.His1746_Arg1751del | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.His1746_Arg1751del | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.Arg905Gln | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.Arg905Gln | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.Arg905Trp | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.Arg905Trp | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.Leu45fs | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.Leu45fs | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.Arg458Ter | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.Arg458Ter | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.Leu493Val | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.Leu493Val | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 c.2356-1G>A | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 c.2356-1G>A | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.Cys887fs | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.Cys887fs | UNSPEC | Driver | Not reported | ClinVar |
| TSC2 p.Gln992Ter | UNSPEC | Driver | Not reported | ClinVar |