Gene dossier

VHL

594 mutation records across 6 cancer labels and 4 source families.

0 actionable105 hotspotsNot reported

Top records

Prioritized variant evidence

Variant	Cancer	Evidence	Frequency	Sources
VHL p.E26G substitution	CHRCC	Likely Driver	1.5%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.H115N substitution	CCRCC	DriverHotspot	1.00%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.L169P substitution	CCRCC	DriverHotspot	0.75%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.R161Q substitution	SOFT_TISSUE	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.W88* substitution	CCRCC	DriverHotspot	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.R161* substitution	CCRCC	DriverHotspot	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.S65* substitution	CCRCC	DriverHotspot	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.L158V substitution	CCRCC	DriverHotspot	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.V74D substitution	CCRCC	DriverHotspot	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.S68* substitution	CCRCC	DriverHotspot	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.D121Y substitution	CCRCC	DriverHotspot	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.N78D substitution	CCRCC	DriverHotspot	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.S111N substitution	CCRCC	DriverHotspot	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.I151T substitution	CCRCC	DriverHotspot	0.50%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.L89H substitution	PRCC	DriverHotspot	0.36%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.G114A substitution	CCRCC	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.S80R substitution	CCRCC	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.S65W substitution	CCRCC	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.Y112* substitution	CCRCC	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.W88L substitution	CCRCC	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.P86T substitution	CCRCC	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.L135F substitution	CCRCC	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.C162R substitution	CCRCC	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.L158P substitution	CCRCC	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.H115Y substitution	CCRCC	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.W117* substitution	CCRCC	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.L158Q substitution	CCRCC	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.W117C substitution	CCRCC	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.L89P substitution	CCRCC	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
VHL p.I151F substitution	CCRCC	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas