Pathway slice
Chromatin
1,230 records across a visible set of 10genes, ranked by hotspot, driver, source, and actionability signals.
Preparing pathway graph...
Ranked pathway records
Evidence table
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| DNMT3A p.R882H | AML | DriverHotspot | 10.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| DNMT3A p.R882P | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| DNMT3A p.R882C | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| DNMT3A p.R882H | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| EZH2 p.Y646S | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| EZH2 p.Y646C | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| EZH2 p.Y646F | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| EZH2 p.Y646H | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| EZH2 p.Y646Y | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| EZH2 p.Y646N | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| ARID1A p.R1989* | UCEC | DriverHotspot | 4.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| H3F3A p.K28R | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| H3F3A p.K28M | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CREBBP p.R1446P | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CREBBP p.R1446C | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CREBBP p.R1446S | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CREBBP p.R1446G | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CREBBP p.R1446H | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| CREBBP p.R1446L | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| SMARCA4 p.T910A | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| SMARCA4 p.T910R | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| SMARCA4 p.T910T | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| SMARCA4 p.T910M | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| ARID1A p.R1989Q | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| ARID1A p.R1989* | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| EP300 p.D1399E | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| EP300 p.D1399Y | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| EP300 p.D1399N | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| KDM6A p.Q555* | BLCA | DriverHotspot | 2.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| DNMT3A p.R882C | AML | DriverHotspot | 3.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| ARID2 p.S297S | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| ARID2 p.S297F | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| ARID2 p.S297F | SKCM | DriverHotspot | 1.6% | cBioPortal, TCGA Pan-Cancer Atlas |
| ARID1A p.R1721* | UCEC | DriverHotspot | 1.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| SMARCB1 p.R377C | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| SMARCB1 p.R377H | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| SMARCB1 p.R377L | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| SMARCA4 p.G1232S | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| SMARCA4 p.G1232C | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| SMARCA4 p.G1232D | Not reported | DriverHotspot | Not reported | Cancer Hotspots |