Pathway slice

DNA Repair

38,052 records across a visible set of 12genes, ranked by hotspot, driver, source, and actionability signals.

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Ranked pathway records

Evidence table

Variant	Cancer	Evidence	Frequency	Sources
BRCA2 p.S2303S substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
BRCA2 p.S2303F substitution	Not reported	DriverHotspotActionable	Not reported	Cancer Hotspots
POLE p.P286R substitution	UCEC	DriverHotspot	3.9%	cBioPortal, TCGA Pan-Cancer Atlas
POLE p.P286R substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
POLE p.P286S substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
POLE p.P286T substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
POLE p.P286H substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
POLE p.P286L substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
POLE p.V411L substitution	UCEC	DriverHotspot	2.1%	cBioPortal, TCGA Pan-Cancer Atlas
POLE p.V411L substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
POLE p.V411L substitution	COADREAD	DriverHotspot	0.75%	cBioPortal, TCGA Pan-Cancer Atlas
POLE p.P286R substitution	UCS	DriverHotspot	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
POLE p.V411L substitution	UCEC	DriverHotspot	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
POLE p.P286R substitution	COADREAD	DriverHotspot	0.37%	cBioPortal, TCGA Pan-Cancer Atlas
POLE p.P286R substitution	PAAD	DriverHotspot	0.56%	cBioPortal, TCGA Pan-Cancer Atlas
POLE p.V411L substitution	CESC	DriverHotspot	0.34%	cBioPortal, TCGA Pan-Cancer Atlas
POLE p.V411L substitution	DIFG	DriverHotspot	0.25%	cBioPortal, TCGA Pan-Cancer Atlas
POLE p.P286R substitution	BLCA	DriverHotspot	0.24%	cBioPortal, TCGA Pan-Cancer Atlas
POLE p.V411L substitution	STAD	DriverHotspot	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
POLE p.P286L substitution	STAD	DriverHotspot	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
POLE p.P286R substitution	BRCA	DriverHotspot	0.09%	cBioPortal, TCGA Pan-Cancer Atlas
POLE p.E18K substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
MSH2 p.E580* substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
RAD51C p.P21A substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
RAD51C p.P21S substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
RAD51C p.P21T substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
PMS2 p.K651R substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
RAD51C p.Y224H substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
BRCA2 p.E1514Q substitution	CHOL	Likely DriverActionable	2.8%	cBioPortal, TCGA Pan-Cancer Atlas
BRCA1 p.S1434N substitution	DLBCLNOS	Likely DriverActionable	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
BRCA1 p.E673K substitution	DLBCLNOS	Likely DriverActionable	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
BRCA2 p.N1805D substitution	UCS	Likely DriverActionable	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
BRCA2 p.L3180F substitution	UCS	Likely DriverActionable	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
BRCA2 p.M1090L substitution	UCS	Likely DriverActionable	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
BRCA2 p.Q3398R substitution	UCS	Likely DriverActionable	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
BRCA2 p.T2367Lfs*9 frameshift	UCS	Likely DriverActionable	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
BRCA2 p.F2841Kfs*24 frameshift	UM	Likely DriverActionable	1.3%	cBioPortal, TCGA Pan-Cancer Atlas
BRCA2 c.7004_7007+2del deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA2 c.7004_7007+2del deletion	UNSPEC	DriverActionable	Not reported	ClinVar
BRCA2 p.Leu2092fs deletion	UNSPEC	DriverActionable	Not reported	ClinVar