Pathway slice

JAK-STAT

72 records across a visible set of 4genes, ranked by hotspot, driver, source, and actionability signals.

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Ranked pathway records

Evidence table

Variant	Cancer	Evidence	Frequency	Sources
STAT3 p.D661V substitution	DLBCLNOS	DriverHotspot	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.E616del deletion	DLBCLNOS	DriverHotspot	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.S614R substitution	DLBCLNOS	DriverHotspot	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.F384L substitution	UCS	DriverHotspot	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.D661Y substitution	CESC	DriverHotspot	0.34%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.H410R substitution	HCC	DriverHotspot	0.27%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.D661Y substitution	STAD	DriverHotspot	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.E616del deletion	STAD	DriverHotspot	0.23%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.D661V substitution	HNSC	DriverHotspot	0.19%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.H410R substitution	LUAD	DriverHotspot	0.18%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.H410R substitution	BRCA	DriverHotspot	0.09%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.F384Y substitution	BRCA	DriverHotspot	0.09%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.H410P substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
STAT3 p.H410R substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SOCS1 p.A3P substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SOCS1 p.A3R substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SOCS1 p.A3T substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SOCS1 p.A3E substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
STAT3 p.E616del inframe	Not reported	DriverHotspot	Not reported	Cancer Hotspots
STAT3 p.S614R substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
STAT3 p.D661V substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
STAT3 p.D661Y substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
STAT3 p.F384V substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
STAT3 p.F384Y substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
STAT3 p.F384L substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
JAK2 p.A676V substitution	UCS	Likely DriverActionable	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
JAK2 p.F439S substitution	UCS	Likely DriverActionable	1.8%	cBioPortal, TCGA Pan-Cancer Atlas
JAK2 p.I328V substitution	ACC	Likely DriverActionable	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
JAK2 p.Val617Phe substitution	UNSPEC	DriverActionable	Not reported	ClinVar
JAK2 p.Val617Phe substitution	UNSPEC	DriverActionable	Not reported	ClinVar
JAK2 p.Lys607Asn substitution	UNSPEC	DriverActionable	Not reported	ClinVar
JAK2 p.Lys607Asn substitution	UNSPEC	DriverActionable	Not reported	ClinVar
JAK2 c.226+1G>T substitution	UNSPEC	DriverActionable	Not reported	ClinVar
JAK2 c.226+1G>T substitution	UNSPEC	DriverActionable	Not reported	ClinVar
SOCS1 p.G122* substitution	DLBCLNOS	Likely Driver	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.Q644R substitution	DLBCLNOS	Likely Driver	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
STAT3 p.Y640F substitution	DLBCLNOS	Likely Driver	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
SOCS1 p.S140T substitution	DLBCLNOS	Likely Driver	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
SOCS1 p.G99Vfs*17 frameshift	DLBCLNOS	Likely Driver	2.4%	cBioPortal, TCGA Pan-Cancer Atlas
SOCS1 p.M161T substitution	DLBCLNOS	Likely Driver	2.4%	cBioPortal, TCGA Pan-Cancer Atlas