Pathway slice
NOTCH
251 records across a visible set of 2genes, ranked by hotspot, driver, source, and actionability signals.
Preparing pathway graph...
Ranked pathway records
Evidence table
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| FBXW7 p.R465P | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R465C | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R465S | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R465G | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R465H | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R465L | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R505P | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R505C | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R505S | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R505G | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R505H | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R505L | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R479P | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R479Q | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R479R | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R479G | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R479* | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R479L | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R465H | COADREAD | DriverHotspot | 2.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R465H | UCEC | DriverHotspot | 1.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R465C | STAD | DriverHotspot | 2.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R465C | UCS | DriverHotspot | 7.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| NOTCH1 p.C359del | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| NOTCH1 p.Y358del | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| NOTCH1 p.S356del | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| NOTCH1 p.F357del | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R465C | COADREAD | DriverHotspot | 1.7% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R658Q | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R658R | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R658* | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R505G | BLCA | DriverHotspot | 2.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R465C | UCEC | DriverHotspot | 1.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R505C | UCEC | DriverHotspot | 1.5% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R689Q | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| FBXW7 p.R689W | Not reported | DriverHotspot | Not reported | Cancer Hotspots |
| NOTCH1 p.F357del | DIFG | DriverHotspot | 1.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R689W | UCEC | DriverHotspot | 1.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R479Q | UCS | DriverHotspot | 5.3% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R505G | HNSC | DriverHotspot | 1.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| FBXW7 p.R658* | UCEC | DriverHotspot | 1.2% | cBioPortal, TCGA Pan-Cancer Atlas |