Pathway slice
PI3K-AKT
4,637 records across a visible set of 7genes, ranked by hotspot, driver, source, and actionability signals.
Preparing pathway graph...
Ranked pathway records
Evidence table
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| PIK3CA p.H1047R | BRCA | DriverHotspotActionable | 12.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | CESC | DriverHotspotActionable | 12.7% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | BRCA | DriverHotspotActionable | 6.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E542K | BRCA | DriverHotspotActionable | 4.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.R88Q | UCEC | DriverHotspotActionable | 7.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | COADREAD | DriverHotspotActionable | 6.6% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | BLCA | DriverHotspotActionable | 7.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.H1047R | UCEC | DriverHotspotActionable | 5.6% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545K | HNSC | DriverHotspotActionable | 5.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E542K | CESC | DriverHotspotActionable | 7.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| PIK3CA p.E545Q | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.E545A | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.E545D | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.E545G | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.E545K | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.H1047Q | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.H1047R | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.H1047Y | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.H1047L | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.E542A | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.E542Q | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.E542V | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.E542G | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.E542K | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.N345T | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.N345D | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.N345H | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.N345I | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.N345Y | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.N345K | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.N345N | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.Q546P | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.Q546R | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.Q546E | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.Q546H | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.Q546K | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.Q546L | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.R88Q | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.M1043T | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| PIK3CA p.M1043V | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |