Pathway slice
RTK-RAS
5,708 records across a visible set of 17genes, ranked by hotspot, driver, source, and actionability signals.
Preparing pathway graph...
Ranked pathway records
Evidence table
| Variant | Cancer | Evidence | Frequency | Sources |
|---|---|---|---|---|
| BRAF p.V600E | THPA | DriverHotspotActionable | 58.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| BRAF p.V600E | SKCM | DriverHotspotActionable | 35.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12D | PAAD | DriverHotspotActionable | 27.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12C | LUAD | DriverHotspotActionable | 12.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12V | PAAD | DriverHotspotActionable | 18.4% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12D | COADREAD | DriverHotspotActionable | 10.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12V | COADREAD | DriverHotspotActionable | 9.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| BRAF p.V600E | COADREAD | DriverHotspotActionable | 9.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12V | LUAD | DriverHotspotActionable | 7.1% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G13D | COADREAD | DriverHotspotActionable | 6.9% | cBioPortal, TCGA Pan-Cancer Atlas |
| BRAF p.V600K | SKCM | DriverHotspotActionable | 8.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| FGFR3 p.S249C | BLCA | DriverHotspotActionable | 7.8% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12R | PAAD | DriverHotspotActionable | 14.0% | cBioPortal, TCGA Pan-Cancer Atlas |
| KRAS p.G12D | UCEC | DriverHotspotActionable | 6.2% | cBioPortal, TCGA Pan-Cancer Atlas |
| BRAF p.V600R | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.V600E | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.V600V | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.V600G | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.V600K | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| BRAF p.V600M | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| EGFR p.L858R | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| KRAS p.Q61P | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| KRAS p.Q61A | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| KRAS p.Q61R | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| KRAS p.Q61E | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| KRAS p.Q61H | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| KRAS p.Q61K | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| KRAS p.Q61L | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| KRAS p.G13A | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| KRAS p.G13R | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| KRAS p.G13C | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| KRAS p.G13D | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| KRAS p.G13E | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| KRAS p.G13V | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| KRAS p.G13G | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| KRAS p.G12A | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| KRAS p.G12R | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| KRAS p.G12C | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| KRAS p.G12S | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |
| KRAS p.G12D | Not reported | DriverHotspotActionable | Not reported | Cancer Hotspots |