Pathway slice

Splicing

130 records across a visible set of 3genes, ranked by hotspot, driver, source, and actionability signals.

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Ranked pathway records

Evidence table

Variant	Cancer	Evidence	Frequency	Sources
SF3B1 p.K700R substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SF3B1 p.K700E substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SF3B1 p.K700K substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
U2AF1 p.S34F substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
U2AF1 p.S34Y substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SF3B1 p.R625C substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SF3B1 p.R625G substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SF3B1 p.R625H substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SF3B1 p.R625L substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SF3B1 p.R625H substitution	UM	DriverHotspot	10.0%	cBioPortal, TCGA Pan-Cancer Atlas
U2AF1 p.S34F substitution	LUAD	DriverHotspot	2.1%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.R625C substitution	UM	DriverHotspot	7.5%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.K700E substitution	BRCA	DriverHotspot	0.94%	cBioPortal, TCGA Pan-Cancer Atlas
U2AF1 p.S34F substitution	AML	DriverHotspot	2.5%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.E902K substitution	BLCA	DriverHotspot	1.5%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.E902Q substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SF3B1 p.E902G substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SF3B1 p.E902K substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SF3B1 p.R625H substitution	SKCM	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
U2AF1 p.S34F substitution	UCS	DriverHotspot	3.5%	cBioPortal, TCGA Pan-Cancer Atlas
U2AF1 p.S34F substitution	UCEC	DriverHotspot	0.77%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.K666T substitution	UM	DriverHotspot	2.5%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.G740E substitution	CHOL	DriverHotspot	2.8%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.K700E substitution	THYM	DriverHotspot	1.6%	cBioPortal, TCGA Pan-Cancer Atlas
U2AF1 p.S34F substitution	PAAD	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas
SRSF2 p.P95L substitution	AML	DriverHotspot	1.0%	cBioPortal, TCGA Pan-Cancer Atlas
U2AF1 p.S34Y substitution	AML	DriverHotspot	1.0%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.K666Q substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SF3B1 p.K666T substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SF3B1 p.K666E substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SF3B1 p.K666M substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
SF3B1 p.K666N substitution	Not reported	DriverHotspot	Not reported	Cancer Hotspots
U2AF1 p.S34F substitution	CESC	DriverHotspot	0.69%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.K666T substitution	HCC	DriverHotspot	0.55%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.R625C substitution	SKCM	DriverHotspot	0.45%	cBioPortal, TCGA Pan-Cancer Atlas
U2AF1 p.I24T substitution	UCEC	DriverHotspot	0.39%	cBioPortal, TCGA Pan-Cancer Atlas
SRSF2 p.Y92_H99del deletion	UM	DriverHotspot	1.3%	cBioPortal, TCGA Pan-Cancer Atlas
SRSF2 p.Y92_H100del deletion	UM	DriverHotspot	1.3%	cBioPortal, TCGA Pan-Cancer Atlas
SF3B1 p.G742D substitution	PLMESO	DriverHotspot	1.2%	cBioPortal, TCGA Pan-Cancer Atlas
U2AF1 p.I24T substitution	ACC	DriverHotspot	1.1%	cBioPortal, TCGA Pan-Cancer Atlas